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Melatonin Hormone Acts on Cells of Maternal Blood and Placenta From Diabetic Mothers
(2022-01-21)
Changes in glucose metabolism of diabetic mothers affect immunological components, proinflammatory factors, and placental hypervascularization that can induce cell death. The hormone melatonin has been identified as a ...
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: Production of N1-acetyl-N2-formyl-5- methoxykynuramine versus radical-mediated degradation
(2007-04-01)
There is a growing body of evidence that melatonin and its oxidation product, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: Production of N1-acetyl-N2-formyl-5- methoxykynuramine versus radical-mediated degradation
(2007-04-01)
There is a growing body of evidence that melatonin and its oxidation product, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland
(BLACKWELL PUBLISHING, 2008-08-15)
Although the fetal pineal gland does not secrete melatonin, the fetus is exposed to melatonin of
maternal origin. In the non-human primate fetus, melatonin acts as a trophic hormone for the
adrenal gland, stimulating ...
New developments in the treatment of primary insomnia in elderly patients : focus on prolonged-release melatonin
(Dove Medical Press, 2012)
Abstract: A temporal relationship between the nocturnal rise in melatonin secretion and the increase in sleep propensity at the beginning of the night, coupled with the sleep-promoting effects of exogenous melatonin, ...
Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
(Multidisciplinary Digital Publishing Institute, 2021-06)
The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic ...
Melatonin : clinical perspectives in neurodegeneration
(Frontiers, 2019)
Abstract: Prevention of neurodegenerative diseases is presently a major goal for our Society and melatonin, an unusual phylogenetically conserved molecule present in all aerobic organisms, merits consideration in this ...
Cytoprotection by Melatonin: The Metabolic Syndrome as an Example
(Springer, 2021)
Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, in part because of its function as a metabolic regulator and mitochondrial protector. As a chronobiotic/cytoprotective agent, melatonin ...
Effect of melatonin on motor performance and brain cortex mitochondrial function during ethanol hangover
(Elsevier, 2014-06)
Increased reactive oxygen species generation and mitochondrial dysfunction occur during ethanol hangover. The aim of this work was to study the effect of melatonin pretreatment on motor performance and mitochondrial function ...
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse
(Elsevier, 2016-07)
The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence they produce, a serious public health problem. Thirty years ago, we demonstrated in experimental animals the interaction of ...