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WNT-5a/ JNK signaling promotes the clustering of PSD-95 in hippocampal neurons.
(2009)
During the formation of synapses, specific regions of pre- and postsynaptic cells associate to form a single functional transmission unit. In this process, synaptogenic factors are necessary to modulate pre- and postsynaptic ...
Modulação da via das MAPKs pelo Vaccinia virus: envolvimento da proteína viral B14 e papel das proteínas celulares JNK e Spir-1
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2016-01-29)
A successful viral replication relies both on cell signaling pathways subversion and evasion from host antiviral responses. Therefore, in favor of its replication and spread, Vaccinia virus (VACV) is well known for its ...
Granulocyte-Colony Stimulating Factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI(3)K in mice
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Granulocyte-colony stimulating factor (G-CSF) is a current pharmacological approach to increase peripheral neutrophil counts after anti-tumor therapies. Pain is most relevant side effect of G-CSF in healthy volunteers and ...
The antiapoptotic effect of 17ß-estradiol in skeletal muscle cells involves PKCδ, JNK and p66Shc
(Elsevier Science Inc, 2016-02)
The hormone 17β-Estradiol (E2) acts on several non-reproductive tissues,including skeletal muscle. We have shown that E2 at physiological concentrations prevented apoptosis induced by hydrogen peroxide (H2O2) in skeletal ...
CFTR modulates RPS27 gene expression using chloride anion as signaling effector
(Elsevier Science Inc, 2017-09)
In Cystic Fibrosis (CF), the impairment of the CFTR channel activity leads to a variety of alterations, including differential gene expression. However, the CFTR signaling mechanisms remain unclear. Recently, culturing ...
Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Equilibrative nucleoside transporters (ENTs) are facilitative transporters broadly selective for pyrimidine and purine nucleosides and are essential for the modulation of nucleoside concentration and nucleoside analog ...
Aneuploidy and tumorigenesis in Drosophila
(Academic Press Ltd - Elsevier Science Ltd, 2014-04)
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative ...
IKK connects autophagy to major stress pathways
(Taylor and Francis Inc., 2010)
Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both ...
The role of the B7-1/2, LFA-3 and ICAM-1 costimulatory molecules in the modulation of T cell responses
(2002)
The physiological activation of T cells to proliferation and cytokine production requires at least two signals. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to T cell, while the second ...