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Estudo funcional da proteína quinase JNK de Schistosoma mansoniatravés de expressão heteróloga no organismo modelo Caenorhabditis elegans
(2013)
A identificação e caracterização dos mecanismos e moléculas envolvidos em
sinalização celular são essenciais para o entendimento da biologia parasitária do S. mansoni. Proteína quinases desempenham papel chave em vias de ...
Análise da influência dos inibidores farmacológicos das vias celulares de MEK/ERK, JNK e PI3K/AKT no ciclo de replicação do vírus da febre amarela
(Universidade Federal de Minas GeraisUFMG, 2011-02-22)
During the process of co-evolution with their hosts, the viruses acquired the capacity of intercept, mimic and usurp several cellular signaling pathways in a way to generate favorable conditions to the replication and ...
Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA
(2013)
Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the ...
17β-estradiol abrogates apoptosis inhibiting PKCδ, JNK and p66Shc activation in C2C12 cells
(Wiley, 2015-05)
17β-Estradiol (E2) protects several non-reproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2O2 in skeletal myoblasts. ...
Increased expression of p21Waf1/Cip1 and JNK with costimulation of prostate cancer cell activation by an siRNA Egr-1 inhibitor
(2013)
The p21Waf1/Cip1 protein (hereafter, p21) and the c‑Jun N-terminal kinase (JNK) are two well-characterized cell modulators that play a crucial role in cell differentiation, senescence and apoptosis. Here, we report that ...
A expressão de interleucina-6 durante infecção pelo Orthopoxvirus Cowpox é regulada pelas MAPKs JNK1/2
(Universidade Federal de Minas GeraisUFMG, 2012-02-03)
The Orthopoxviruses Vaccinia (VACV) and Cowpox (CPXV) belong to the Poxviridae family, the largest and more complex animal DNA viruses, whose replication occurs in the cytoplasmic compartment of the infected cells. Even ...
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling
(2019)
During the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, ...
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. These cells ...
The JNK Pathway Is a Key Mediator of Anopheles gambiae Antiplasmodial Immunity
(Public Library of Science, 2021)
Modulation of the jnk and p38 pathways by cdk5 protein kinase in a transgenic mouse model of alzheimers disease
(LIPPINCOTT WILLIAMS & WILKINS, 2003)