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In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo
(Frontiers Media SA, 2018)
Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions
(Elsevier GmbH, 2019)
Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections
(Frontiers media SA, 2017)
Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy
(Nature, 2014)
Background: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of
cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid ...
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
(Nature Publishing Group, 2016)
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy
(Nature Publishing Group, 2014)
© 2014 Cancer Research UK. Background:Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T ...
Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity
(Cancer Research UK, 2015)
Background: Alterations in connexin 43 (Cx43) expression and/or gap junction (GJ)-mediated intercellular communication are implicated in cancer pathogenesis. Herein, we have investigated the role of Cx43 in melanoma cell ...
Las células dendríticas en la infección por el VIH-1.
(2012-12-12)
Las células dendríticas son un componente de la inmunidad innata que cumple con la función crucial de activar los linfocitos
T vírgenes. Son una de las células blanco de la infección por el VIH-1, aunque la replicación ...
The autophagy protein pacer positively regulates the therapeutic potential of mesenchymal stem cells in a mouse model of DSS-induced colitis
(MDPI, 2022)
Mesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using ...
Early-stage diffuse large B cell lymphoma of the head and neck: clinico-biological characterization and 18 year follow-up of 488 patients (IELSG 23 study)
(Springer, 2014)
It is known that extranodal head and neck diffuse
large B cell lymphomas (eHN-DLBCL) can affect various
anatomical structures what is not well-known, however, is
whether they differ in terms of clinical presentation and ...