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Molecular mechanisms of hypertensive nephropathy: Renoprotective effect of losartan through hsp70
(Multidisciplinary Digital Publishing Institute, 2021-11)
Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease after diabetes. For years, hypertensive kidney disease has been focused on the afferent arterioles and glomeruli damage and the ...
Association of the C−344T aldosterone synthase gene variant with essential hypertension : a meta-analysis
(Lippincott Williams, 2007-01)
Background: The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been associated with essential hypertension and some, but not all, studies have reported that the C−344T variant may influence the risk of the disease. ...
Hypertension and Insulin Resistance: Implications of Mitochondrial Dysfunction
(Springer, 2014-11)
Mitochondria are the primary generators of cellular reactive oxygen species (ROS); their pathophysiological roles in hypertension and insulin resistance are but imperfectly understood. Mitochondrial dysfunction has been ...
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy
(Springer/Plenum Publishers, 2019-05)
Worldwide, raised blood pressure is estimated to affect 35–40% of the adult population and is a main conditioning factor for cardiovascular diseases and stroke. Animal models of hypertension have provided great advances ...
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions
(American Society for Microbiology, 2015-06)
Hypertension-associated cardiorenal diseases represent one of the heaviest burdens for current health systems. In addition to hemodynamic damage, recent results have revealed that hematopoietic cells contribute to the ...
Melatonin corrective effect on systemic and vascular hemodynamic parameters in patients with the first degree of arterial hypertension suffering from sleep disorders
(Academia Nacional de Medicina venezolana., 2022)
Characteristics and Determinants of Pulse Pressure-age Relationship in Healthy and Non-treated Hypertensive Subjects of an Argentinean Population
(Bentham Science Publishers, 2020-12)
Background: The relationship between the increases in pulse pressure (PP) and arterial stiffness determined by aging or systemic hypertension has been widely reported. These findings are supported by large-cohort analyzes ...
Misleading guidelines for the diagnosis and management of hypertension
(HCPA/FAMED/UFRGS, 2014)
The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
(Sociedad Argentina de Cardiología, 2010-08)
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide ...
Protection of cardiac cell-to-cell coupling attenuate myocardial remodeling and proarrhythmia induced by hypertension
(Acad Sciences Czech Republic, 2016-09)
Gap junction connexin channels are important determinants of myocardial conduction and synchronization that is crucial for coordinated heart function. One of the main risk factors for cardiovascular events that results in ...