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Hyaluronan as drug carrier. The in vitro efficacy and selectivity of Hyaluronan-Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells
(Elsevier Science, 2014-09)
We report Doxorubicin ionic complexes with hyaluronic acid (HiH-Dx) or its sodium salt (HiNa-Dx) as tumor-targeting delivery system. The complexes were prepared in situ by mixing aqueous solutions of Dx.HCl with HiH or ...
The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
(Codon Publications, 2019)
There is a growing evidence that supports the role of the tumor microenvironment (TME) in the development and progression of cancer. TME is composed of cellular components, bioactive substances (e.g. growth factors) and ...
Low Molecular Weight Hyaluronan-Pulsed Human Dendritic Cells Showed Increased Migration Capacity and Induced Resistance to Tumor Chemoattraction
(Public Library of Science, 2014-09)
We have shown that ex vivo pre-conditioning of bone marrow-derived dendritic cells (DC) with low molecular weight hyaluronan (LMW HA) induces antitumor immunity against colorectal carcinoma (CRC) in mice. In the present ...
Low molecular weight hyaluronan induces migration of human choriocarcinoma JEG-3 cells mediated by RHAMM as well as by PI3K and MAPK pathways
(Springer, 2017-08)
Hyaluronan (HA) is the major glycosaminoglycan present in the extracellular matrix. It is produced by some tumours and promotes proliferation, differentiation and migration among others cellular processes. Gestational ...
Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis
(ELSEVIER SCIENCE INC, 2009)
Introduction: Hyaluronidases (HAases) are enzymes related to cancer progression. Isoforms of HAases have been described as products of alternative splicing responsible for differences in enzyme activity. The heterogeneity ...
Hyaluran-itaconic acid-glutaraldehyde films for biomedical applications: Preliminary studies
(MDPI, 2015-07-29)
New hyaluronic acid?itaconic acid films were synthesized as potential materialswith biomedical applications. In this work, we explored the homogeneous crosslinkingreactions of hyaluronic acid using glutaraldehyde in the ...
Experimental tendon repair: Glycosaminoglycan arrangement in newly synthesized collagen fibers
(Cellular & Molecular BiologyNoisy-le-grandFrança, 2003)