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Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
(Nature Research, 2015)
Abstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast ...
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
(Impact Journals, 2017)
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical ...
Immunomodulatory role of histamine H4 receptor in breast cancer
(Springer, 2019)
BACKGROUND: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its
immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of ...
Envenenamento ofídico em crianças: frequência de reações precoces ao antiveneno em pacientes que receberam pré-tratamento com antagonistas H1 e H2 da histamina e hidrocortisonaSnake envenomation in children: early reactions frequency at antivenom in patients pretreated with histamine antagonists HI and H2 and hydrocortisone
(Instituto de Medicina Tropical, 1994)
Efeito analgésico de antagonistas do receptor da histamina H1 em modelo de dor provocada por formalina em ratos
(Sociedade Brasileira de Anestesiologia, 2009)
JUSTIFICATIVA E OBJETIVOS: Os receptores de histamina mediam vias nociceptivas principalmente no sistema nervoso central. Alguns estudos mostraram efeito analgésico de antagonistas de receptor de histamina no sistema nervoso ...
Antitumor activity of histamine and clozapine in a mouse experimental model of human melanoma
(Elsevier, 2013-12)
Functional presence of histamine H4 receptor (H4R) was demonstrated in human melanoma cell lines and biopsies. Objective: The purposes of this work were to investigate signal transduction pathways and biological responses ...
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor
(Springer Nature, 2017)
Abstract: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the thera- peutic effect of BNCT mediated by BPA ...
Efeito analgésico de antagonistas do receptor da histamina H2 em modelo de dor provocada por formalina em ratos
(Sociedade Brasileira para o Estudo da Dor, 2011)
JUSTIFICATIVA E OBJETIVOS: Antagonistas de receptor de histamina apresentam efeitos sobre a dor. Antagonistas de receptor H1 apresentam efeito analgésico local, o papel de antagonistas de receptor H2 sobre a dor no sistema ...