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Genetic transformation of Diaporthe phaseolorum, an endophytic fungus found in mangrove forests, mediated by Agrobacterium tumefaciens
(SPRINGERNEW YORK, 2012-02)
We describe the genetic transformation of the mycelial tissue of Diaporthe phaseolorum, an endophytic fungus isolated from the mangrove species Laguncularia racemosa, using Agrobacterium tumefaciens-mediated transformation ...
Efficient plasmid-mediated gene transfection of ovine bone marrow mesenchymal stromal cells
(Elsevier, 2013-01)
BACKGROUND AIMS: Given the close similarity between ovine and human cardiomyocytes, sheep models of myocardial infarction and heart failure are increasingly used in studies of stem cell-mediated heart regeneration. In these ...
High rates of bovine blastocyst development after ICSI-mediated gene transfer assisted by chemical activation
(Elsevier Science Inc, 2010-10)
In order to establish conditions for intracytoplasmic sperm injection-mediated gene transfer (ICSI-MGT) in cattle, various aspects of fertilization and embryonic development were assessed after five activation treatments. ...
A new adenovector system for implementing thymulin gene therapy for inflammatory disorders
(Pergamon-Elsevier Science Ltd, 2017-07)
Thymulin is a thymic peptide possessing anti-inflammatory effects. In order to manipulate thymulin expression in gene therapy studies, we built a bidirectional regulatable two-vector Tet-Off system and the corresponding ...
Desenvolvimento de plataforma bacteriana para produção de biofármacos
(Universidade Estadual Paulista (Unesp), 2021-08-16)
A produção de biofármacos tem crescido rapidamente em todo o mundo. Porém, o processo de produção e purificação destas biomoléculas é bastante custoso. A solução para minimizar tais custos pode estar associada ao desenvolvimento ...
Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells
(2021)
Connexins (Cxs) are a family of proteins that form two different types of ion channels: hemichannels and gap junction channels. These channels participate in cellular communication, enabling them to share information and ...
Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract
(Springer Heidelberg, 2018-09)
Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue ...
Focal Adhesion Dynamics Are Altered in Schizophrenia
(Society of Biological Psychiatry, 2013)
Background: Evidence from genetic association studies implicate genes involved in neural migration associated with schizophrenia
risk. Neural stem/progenitor cell cultures (neurosphere-derived cells) from olfactory mucosa ...
Connexin46 expression enhances cancer stem cell and epithelial-to-mesenchymal transition characteristics of human breast cancer mcf-7 cells
(2021-11-01)
Connexins (Cxs) are a family of proteins that form two different types of ion channels: hemichannels and gap junction channels. These channels participate in cellular communication, enabling them to share information and ...
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
(2022-07)
Parkinson's disease is a neurodegenerative disorder that involves the death of the dopaminergic neurons of the nigrostriatal pathway and, consequently, the progressive loss of control of voluntary movements. This ...