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Mostrando ítems 2451-2460 de 4998
Determinatiom of 8-Hydroxy 2′-Deoxyguanosine Using Electrodes Modified with a Dispersion of Carbon Nanotubes in Polyethylenimine
(Wiley VCH Verlag, 2011-05)
Hydroxyl radicals easily oxidize biomolecules such as proteins and DNA. The most abundant oxidative product of DNA is 8-hydroxy 2?-deoxyguanosine (8-OHdG) and this is considered a biomarker of oxidative DNA damage. This ...
Evaluation of Cytotoxicity and Genotoxicity of Acacia aroma Leaf Extracts
(Hindawi Publishing Corporation, 2014-09)
Acacia aroma, native plant from San Luis, Argentina, is commonly used as antiseptic and for healing of wounds. The present study was conducted to investigate the in vitro cytotoxicity and genotoxicity of hot aqueous extract ...
Nanosecond pulsed electric field (nsPEF) and vaccines : a novel technique for the inactivation of SARS-CoV-2 and other viruses?
(2022)
Since the beginning of 2020, worldwide attention has been being focussed on SARS-CoV-2, the second strain of the severe acute respiratory syndrome virus. Although advances in vaccine technology have been made, particularly ...
Avaliação do efeito modulador de diferentes estatinas sobre danos ao DNA induzidos pela doxorrubicina em células somáticas de Drosophila melanogaster
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Genética e BioquímicaCiências BiológicasUFU, 2016)
Aspectos bio y agroclimáticos del cultivo de vid para vinificar en el Valle Inferior del Río Negro
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2016-10-26)
El cultivo de vid (Vitis vinífera L.) con destino a uva para vinificar tuvo una expansión importante en los últimos años en la región norpatagónica Argentina. En Río Negro, el valle de Viedma (40º48’ S y 63º05’ O) se ha ...
Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12
(Public Library of Science, 2014-02)
For more than a decade, the cytokine interleukin-12 (IL-12) has been utilized, either alone or in combination with otherdrugs, as a treatment for cancer. The numerous anti-tumor properties of IL-12 still generate interest ...
AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress
(Nature Publishing Group, 2019-05)
Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point of therapeutic intervention in ...
Alterações na homeostase redox e do retículo endoplasmático: mecanismos associados à lipodistrofia generalizada congênita do tipo 2
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2019-04-09)
Congenital generalized lipodystrophy (CGL) type 2 consists of a rare autosomal recessive
syndrome characterized by almost complete lack of body fat at birth. CGL, genetically
caused by loss-of-function mutations in the ...