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Synthesis, structural characterization and pro-apoptotic activity of Indanone thiosemicarbazones and their platinum (II) and paladium (II) complexes: Potential role as selective antileukemic agents
(Wiley VCH Verlag, 2011)
In the search for alternative chemotherapeutic strategies against leukemia, various 1-indanone thiosemicarbazones, as well as eight novel platinum(II) and palladium(II) complexes, with the formula [MCl2(HL)] and ...
C4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative
(OXFORD UNIV PRESS, 2011)
Background. Sensitized patients (pts) may develop acute antibody-mediated rejection (AMR) due to preformed donor-specific antibodies, undetected by pre-transplant complement-dependent cytotoxicity (CDC) crossmatch (XM). ...
Study of a series of cobalt(II) sulfonamide complexes: synthesis, spectroscopic characterization, and microbiological evaluation against M. tuberculosis. Crystal structure of [Co(sulfamethoxazole)2(H2O)2]H2O
(Elsevier BVAmsterdam, 2013-03)
Nowadays, the research for new and better antimicrobial compounds is an important field due to the increase of immunocompromised patients, the use of invasive medical procedures and extensive surgeries, among others, that ...
Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents
(ElsevierPhiladelphia, 2014-03)
Through a systematic variation on the structure of a series of manganese complexes derived from 2-acetylpyridine-N(4)-R-thiosemicarbazones (Hatc-R), structural features have been investigated with the aim of obtaining ...
Antileishmanial Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea
(GEORG THIEME VERLAG KG, 2011)
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane ...
Antitumor effects of snake venom chemically modified Lys49 phospholipase A(2)-like BthTX-I and a synthetic peptide derived from its C-terminal region
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2009)
The present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-I and its cationic synthetic peptide derived from the 115-129 C-terminal region. BPB-BthTX-1 presented cytotoxicity of 10-40% ...
A phenolic-rich extract from ugni molinae berries reduces abnormal protein aggregation in a cellular model of huntington's disease
(Public Library Science, 2021)
Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds ...
Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity
(Elsevier Ltd, 2019-04)
Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N 5 ,N 10 -dioxide. This compound ...
Active composite starch films containing green synthetized silver nanoparticles
(Elsevier, 2017-09)
The aims of this work were to couple both the silver nanoparticles (AgNPs) synthesis, and filmogenic suspensions preparation, to characterize the obtained AgNPs and the derived nanocomposite films studying their antimicrobial ...
Green by design: Convergent synthesis, computational analyses, and activity evaluation of new fxa inhibitors bearing peptide triazole linking units
(MDPI, 2021-12)
Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a ...