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C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis
(Elsevier B.V., 2007-04-20)
The inhibitory capacity of C-Npys (S-[3-nitro-2-pyridinesulenyl]) derivatives over thiol-containing serine proteases has never been tested. in the present work we used an extracellular serine-thiol protemase activity from ...
146 Heparan sulfate is involved in nuclear sperm decondensation after fertilization in bovine
(Csiro Publishing, 2016-12-02)
Reduced glutathione (GSH) is an endogenous disulfide bond reducer present in mammalian oocytes. It plays a critical role in sperm decondensation following fertilization, disrupting the protamine bonds that sustain the ...
Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database
(2021)
Alzheimer's disease is the most common form of dementia, representing 60-70% of dementia cases. The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination ...
Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases
(Plenum Publ Corp, 1995-11-01)
Peptide segments derived from consensus sequences of the inhibitory site of cystatins, the natural inhibitors of cysteine proteinases, were used to develop new substrates and inhibitors of papain and rat liver cathepsins ...
Immobilization of Carboxypeptidase A into Modified Chitosan Matrixes by Covalent Attachment
(Humana Press, 2018-08)
Carboxypeptidase A (CPA) is a metalloexopeptidase that catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. The enzyme preferentially cleaves over C-terminal L-amino ...
The effect of alpha-tocopherol on the oxidative cleavage of beta-carotene
(Elsevier B.V., 2000-07-15)
Two cleavage pathways of beta-carotene have been proposed, one by central cleavage and the other by random (excentric) cleavage. The central cleavage pathway involves the metabolism of beta-carotene at the central double ...
The effect of alpha-tocopherol on the oxidative cleavage of beta-carotene
(Elsevier B.V., 2000-07-15)
Two cleavage pathways of beta-carotene have been proposed, one by central cleavage and the other by random (excentric) cleavage. The central cleavage pathway involves the metabolism of beta-carotene at the central double ...
Staphylococcus aureus Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism
(Mdpi, 2022-09-01)
Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action mechanisms. To date, four ETs have been ...
PROTEASES ASSOCIATED WITH Mycobacterium tuberculosis INFECTIONPROTEASES ASSOCIATED WITH Mycobacterium tuberculosis INFECTION
(Universidade Federal de Goiás, 2019)
Characterization of a Novel Thermostable Enzyme from Thermus sp. 2.9 with Phospholipase and Acyltransferase Activities
(Karger, 2018)
Phospholipases are classified in different enzyme families according to the ester bond they cleave within phospholipids. The use of phospholipases in industrial processes has prompted the search for new enzymes with ...