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Predicting HLA CD4 immunogenicity in human populations
(Frontiers Media S.A., 2018-06)
Background: Prediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications. HLA binding affinity ...
Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors
(Public Library of Science, 2020)
Background: Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis ...
Positive predictive value surfaces as a complementary tool to assess the performance of virtual screening methods
(Bentham Science Publishers, 2020-05)
Background: Since their introduction in the virtual screening field, Receiver Operating Characteristic (ROC) curve-derived metrics have been widely used for benchmarking of computational methods and algorithms intended for ...
Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort
(Springer, 2020)
Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medical research; however, few studies have been conducted in low- and middle-income countries (LMICs), especially in South America. This ...
NetH2pan: A computational tool to guide MHC peptide prediction on murine tumors
(American Association for Cancer Research, 2018-06)
With the advancement of personalized cancer immunotherapies, new tools are needed to identify tumor antigens and evaluate T-cell responses in model systems, specifically those that exhibit clinically relevant tumor ...
Automated analysis of free speech predicts psychosis onset in high-risk youths
(2015-08-26)
BACKGROUND/OBJECTIVES: Psychiatry lacks the objective clinical tests routinely used in other specializations. Novel
computerized methods to characterize complex behaviors such as speech could be used to identify and predict ...
Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae.
(Oxford University Press, 2022)
BACKGROUND: Aminoglycoside-containing regimens may be an effective treatment option for infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but aminoglycoside-resistance genes are common in these ...
Diagnostic Value of Combined Acute Levodopa Challenge and Olfactory Testing to Predict Parkinson's Disease
(Wiley, 2017-11)
Background: The diagnosis of Parkinson's disease (PD) can be challenging early in the diseasecourse, when motor features are subtle. The objective of this study was to explore the diagnostic value ofcombining acute levodopa ...