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Antinociception, tolerance, and physical dependence comparison between morphine and tramadol
(Elsevier Inc., 1998)
The mechanism of action of tramadol includes the activation of opioid receptors, and the potential ability of the drug to induce tolerance and physical dependence has been evaluated in different animal species and humans. ...
Synergy between the antinociceptive effects of morphine and NSAIDs
(2004)
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...
Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol
(2007)
The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain). Isobolographic ...
Antinociception induced by rosuvastatin in murine neuropathic pain
(Elsevier, 2018-06)
Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
Previous administration of indomethacin or naloxone did not influence ketorolac antinociception in mice
(1993)
We studied the effects of the inhibition of prostaglandin biosynthesis and opioid antagonism in the antinociceptive action of ketorolac using the mouse acetic acid writhing test. Ketorolac was administered via the ...
Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice
(2012)
Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction ...
Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice
(2009)
The purpose of the present study was to evaluate the nature of the antinociceptive interaction among dexketoprofen (DEX), a mixed inhibitor of the cyclo-oxygenases, and tramadol (TRAM), a weak opioid with monoaminergic ...
Spinal synergy between nonselective cyclooxygenase inhibitors and morphine antinociception in mice
(ELSEVIER SCIENCE, 2005-07-12)
The antinociception induced by the intrathecal coadministration of combinations of morphine with the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen, piroxicam, metamizol, diclofenac and ketoprofen was studied by ...
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS)
(2009)
To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction ...
Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs
(Polish Academy of Sciences, 2009)
To enhance analgesia, the combinatorial use of analgesic drugs with proven efficacies is a widely-used strategy to reduce adverse side effects. The present study characterizes the antinociceptive interaction of intrathecal ...