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Avaliação da efetividade e segurança dos agentes Anti-TNF utilizados no tratamento de pacientes com Artrite Reumatoide em Minas Gerais
(Universidade Federal de Minas GeraisUFMG, 2016-08-04)
Rheumatoid arthritis (RA) is an inflammatory, systemic and progressive disease that leads to deformity and destruction of joints. RA needs treatment for a long time resulting in high costs for the Brazilian Unified Health ...
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets
(2011)
The aim of this work was to study the effect of anti-TNF treatment on CD4+ Th1, Th17 and regulatory T cells (Tregs), together with CD8+ T cells and NK cells from rheumatoid arthritis (RA) patients. For this purpose, 18 RA ...
Diabetes reduces mesenchymal stem cells in fracture healing through a TNF alpha-mediated mechanism
(Springer, 2015-03-01)
Diabetes interferes with bone formation and impairs fracture healing, an important complication in humans and animal models. The aim of this study was to examine the impact of diabetes on mesenchymal stem cells (MSCs) ...
Immunogenicity to biological drugs in psoriasis and psoriatic arthritis
(Hospital Clinicas, Brasil, 2021)
Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological ...
Mild hypothermia upregulates myc and xbp1s expression and improves anti TNF alpha production in CHO cells
(Public Library Science, 2018)
Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome. Mild hypothermia has ...
A guide to preparation of patients with inflammatory bowel diseases for anti-TNF-alpha therapy
(Int Scientific Literature, Inc, 2014-03-26)
Current therapy of moderate-to-severe inflammatory bowel disease (IBD) often involves the use of anti-tumor necrosis factor alpha (TNF-alpha) agents. Although very effective, theses biologics place the patient at increased ...
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
(Sociedad de Biología de Chile, 2008)
Effects of anti-TNF therapy on glucose metabolism in patients with ankylosing spondylitis, psoriatic arthritis or juvenile idiopathic arthritis
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010)
The objective of this study was to evaluate the influence of anti-tumor necrosis factor (anti-TNF) in juvenile idiopathic arthritis (DA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA). Sixty-two patients were ...