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Involvement of GABAergic mechanisms of the dorsal periaqueductal gray and inferior colliculus on unconditioned fear
(Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, 2009)
The fact that the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), together with superior colliculus, medial hypothalamus and amygdala, constitute the brain aversion system has been well-established. Stepwise ...
Voxel-based morphometry findings in Alzheimer's disease: neuropsychiatric symptoms and disability correlations - preliminary results
(Faculdade de Medicina / USP, 2011)
INTRODUCTION: The role of structural brain changes and their correlations with neuropsychiatric symptoms and disability in Alzheimer's disease are still poorly understood. OBJECTIVE: To establish whether structural changes ...
Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine
(SAGE PUBLICATIONS LTD, 2010)
Previous functional magnetic resonance imaging (fMRI) studies examined neural activity responses to emotive stimuli in healthy individuals after acute/subacute administration of antidepressants. We now report the effects ...
Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [(18)F]Fluorodeoxyglucose-Positron-Emission Tomography Study with Partial Volume Effects Correction
(AMER SOC NEURORADIOLOGY, 2011)
BACKGROUND AND PURPOSE: Functional brain variability has been scarcely investigated in cognitively healthy elderly subjects, and it is currently debated whether previous findings of regional metabolic variability are ...
Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Objective: Impulsivity is associated with the clinical outcome and likelihood of risky behaviors among bipolar disorder (BD) patients. Our previous study showed an inverse relationship between impulsivity and orbitofrontal ...
A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
The elevated plus-maze is an animal model used to study anxiety. In a second session, rats show a reduction in the exploratory behavior even when the two sessions are separated by intervals as large as 7 days. The aim of ...
Distinct Effects of Delta 9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
(AMER MEDICAL ASSOC, 2009)
Context: Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. Objective: To investigate the effects of 2 main psycho-active constituents of Cannabis ...
Lateral Parabrachial Afferent Areas and Serotonin Mechanisms Activated by Volume Expansion
(WILEY-LISS, 2008)
Recent evidence has shown that the serotonergic mechanism of the lateral parabrachial nucleus (LPBN) participates in the regulation of renal and hormonal responses to isotonic blood volume expansion (BVE). We investigated ...
CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within the hypothalamus, Kiss1 mRNA is expressed ...
5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Activation of 5-HT2C receptors in limbic structures such as the amygdala and hippocampus increases anxiety. Indirect evidence obtained with non-selective 5-HT2C-interacting drugs suggests that the same may occur in the ...