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Chronic in vitro exposure to 3′-azido-2′, 3′-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells
(Springer, 2001-03)
Normal cells in culture divide a certain amount of times and undergo a process termed replicative senescence. Telomere loss is thought to control entry into senescence. Activation of telomerase in tumors bypasses cellular ...
Pharmaceutical polymorphism of a 5´-O-oxalatoyl prodrug of zidovudine (azidothymidine)
(Open Science Publishers LLP, 2020-03)
The importance of polymorphism in pharmaceuticals makes its study relevant. The aim of this study was to investigate the solid-state forms in which 3´-azido-2´,3´-dideoxi-5´-O-oxalatoyl-thymidinic acid (AZT-Ac), a zidovudine ...
Down Modulation of TNF-α mRNA Placental Expression by AZT Used for the Prevention of HIV-1 Mother-to-Child Transmission
(W B Saunders Co Ltd, 2006-09)
Mechanisms of HIV-1 in utero mother-to-child transmission (MTCT) protection provided by AZT are not completely understood. The placental cytokine network is involved in the control of HIV-1 in utero transmission but the ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Michel Graulich, Le sacrifice humaine chez les Azt¨ques
(Instituto de Investigaciones Históricas, 2009)
Dispersões sólidas mucoadesivas para administração oral de zidovudina
(Universidade Estadual Paulista (UNESP), 2015)
Development and In Vitro Evaluation of Surfactant Systems for Controlled Release of Zidovudine
(John Wiley & Sons Inc, 2010-05-01)
The development of a controlled-release dosage form of zidovudine (AZT) is of crucial importance, in view of the pharmacokinetics of its toxic activity. A suitable drug delivery system could increase AZT bioavailability, ...
Development and In Vitro Evaluation of Surfactant Systems for Controlled Release of Zidovudine
(John Wiley & Sons Inc, 2010-05-01)
The development of a controlled-release dosage form of zidovudine (AZT) is of crucial importance, in view of the pharmacokinetics of its toxic activity. A suitable drug delivery system could increase AZT bioavailability, ...