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Synthesis, X-ray Crystal Structure and Theoretical Calculations of Antileishmanial Neolignan Analogues
(Soc Brasileira Quimica, 2010-01-01)
The synthesis and X-ray crystal diffraction structure of two analogues of neolignans, 2-(4-chlorophenyl)-1-phenylethanone (20) and 2-[(4-chlorophenyl)thio]-1-(3,4-dimethoxyphenyl)propan-1-one (12) is described. The compound ...
Synthesis, X-ray Crystal Structure and Theoretical Calculations of Antileishmanial Neolignan Analogues
(Soc Brasileira Quimica, 2010-01-01)
The synthesis and X-ray crystal diffraction structure of two analogues of neolignans, 2-(4-chlorophenyl)-1-phenylethanone (20) and 2-[(4-chlorophenyl)thio]-1-(3,4-dimethoxyphenyl)propan-1-one (12) is described. The compound ...
MD simulations and multivariate studies for modeling the antileishmanial activity of peptides
(Wiley-Blackwell, 2017-10-01)
Leishmaniasis, a protozoan-caused disease, requires alternative treatments with minimized side-effects and less prone to resistance development. Antimicrobial peptides represent a possible choice to be developed. We report ...
Dillapiole as Antileishmanial Agent: Discovery, Cytotoxic Activity and Preliminary SAR Studies of Dillapiole Analogues
(WILEY-V C H VERLAG GMBHWEINHEIM, 2012)
In this paper, the isolation of dillapiole (1) from Piper aduncum was reported as well as the semi-synthesis of two phenylpropanoid derivatives [di-hydrodillapiole (2), isodillapiole (3)], via reduction and isomerization ...
Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L.
(European Journal of Medicinal Chemistry, 2018)
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines
(Elsevier, 2015)
A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC(50) values lower than standard drugs. Brief SAR analysis revealed ...