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Serotoninergic receptors in the anteroventral preoptic region modulate the hypoxic ventilatory response
(Elsevier B.V., 2006-08-01)
Hypothalamus is a site of integration of the hypoxic and thermal stimuli on breathing and there is evidence that serotonin (5-HT) receptors in the anteroventral preoptic region (AVPO) mediate hypoxic hypothermia. Once 5-HT ...
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes
(Nature Publishing Group, 2004-02-04)
1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs),
including 4-I¼2C-I, 4-Br¼2C-B, and 4-CH3¼2C-D analogs, are partial agonists at 5-HT2C
receptors, and show low or even negligible ...
Medial amygdaloid nucleus 5-HT2C receptors are involved in the hypophagic effect caused by zimelidine in rats
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
The medial amygdaloid nucleus (MeA) is a sub-region of the amygdaloid complex that has been described as participating in food intake regulation. Serotonin has been known to play an important role in appetite and food ...
A chemometric study of the 5-HT1A receptor affinities presented by arylpiperazine compounds
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2008)
Arylpiperazine compounds are promising 5-HT1A receptor ligands that can contribute for accelerating the onset of therapeutic effect of selective serotonin reuptake inhibitors. In the present work, the chemometric methods ...
5-HT3 receptor within the amygdaloid complex modulates pain hypersensitivity induced by empathy model of cohabitation with a partner in chronic pain condition in mice
(2021-01-01)
Cohabitation with a partner undergoing chronic pain induces pain hypersensitivity. Among a lot of other neurochemical pathways, the serotonin (5-HT) role, specifically the 5-HT3 receptor (5-HT3R), in the amygdala has never ...
Role of 5-HT1A receptors in the ventral hippocampus in the regulation of anxiety- and panic-related defensive behaviors in rats
(2021-06-25)
Changes in 5-HT1A receptor (5-HT1AR)-mediated neurotransmission in the hippocampus have been associated with anxiety, depression and in the mode of action of antidepressant drugs. It has been commonly accepted that whereas ...
Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands
(BENTHAM SCIENCE PUBL LTD, 2008)
5-HT(1A) receptor plays an important role in the delayed onset of antidepressant action of a class of selective serotonin reuptake inhibitors. Moreover, 5-HT(1A) receptor levels have been shown to be altered in patients ...
Unraveling Mechanisms Underlying Partial Agonism in 5-HT3A receptors
(Society For Neuroscience, 2014-12)
Partial agonists have emerged as attractive therapeutic molecules. 2-Me-5HT and tryptamine have been defined as partial agonists of 5-HT3 receptors on the basis of macroscopic measurements. Because several mechanisms may ...
Role of serotonergic 5-HT1A and oxytocinergic receptors of the lateral septal area in sodium intake regulation
(Elsevier B.V., 2010-06-19)
Several reports have revealed a high density of 5-HT1A receptors in the lateral septal area (LSA), as well as a subpopulation of oxytocin (OT) receptors. Increasing evidence shows that 5-HT1A and OT neurons inhibit sodium ...
Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT(1A) and 5-HT(2A) receptors in the rat dorsal periaqueductal gray
(SPRINGER, 2008)
Rationale Serotonin in the dorsal periaqueductal gray (DPAG) through the activation of 5-HT(1A) and 5-HT(2A) receptors inhibits escape, a defensive behavior associated with panic attacks. Long-term treatment with antipanic ...