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Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
(2023-05-15)
Animal survival depends on cognitive abilities such as learning and memory to adapt to environmental changes. Memory functions require an enhanced activity and connectivity of a particular arrangement of engram neurons, ...
Electrical properties and functional expression of ionic channels in cochlear inner hair cells of mice lacking the α10 nicotinic cholinergic receptor subunit
(Springer, 2009-06)
Cochlear inner hair cells (IHCs) release neurotransmitter onto afferent auditory nerve fibers in response to sound stimulation. During early development, synaptic transmission is triggered by spontaneous Ca2+ spikes which ...
Estudos computacionais de ligantes dos receptores nicotínicos de acetilcolina do subtipo α4β2
(Universidade Estadual Paulista (Unesp), 2019-02-26)
Os nAChRs (receptores nicotínicos de acetilcolina) são canais iônicos pentaméricos que respondem ao neurotransmissor endógeno acetilcolina, com os subtipos α4β2 e α7 sendo expressos em grandes quantidades no cérebro humano. ...
Estudios computacionales sobre los receptores nicotínicos de acetilcolina subtipos α4β2 y α7
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)
Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes
(Elsevier Science Ltd., 2002-12-19)
Cytisine (cy) is a potent and competitive partial agonist at α4 subunit-containing nicotinic acetylcholine (nACh) receptors while
at homomeric α7-nACh receptors it behaves as a full agonist with a relatively lower potency. ...
A deep learning-based approach to model anomalous diffusion of membrane proteins: the case of the nicotinic acetylcholine receptor
(Oxford University Press, 2022)
Abstract:
We present a concatenated deep-learning multiple neural network system for the analysis of single-molecule trajectories. We apply this machine learning-based analysis to characterize the translational diffusion ...
A deep learning-based approach to model anomalous diffusion of membrane proteins: The case of the nicotinic acetylcholine receptor
(Oxford University Press, 2021-10)
We present a concatenated deep-learning multiple neural network system for the analysis of single-molecule trajectories. We apply this machine learning-based analysis to characterize the translational diffusion of the ...
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity
(2019-02-01)
Parkinson’s disease (PD) is a neurodegenerative pathology characterized by resting tremor, rigidity, bradykinesia, and loss of dopamine-producing neurons in the pars compacta of the substantia nigra in the central nervous ...