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The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials

Universidade Estadual Paulista (UNESP); Universidade Federal do Rio Grande do Sul (UFRGS); Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) (2007-03-01)

EPSP synthase (EPSPS) is an essential enzyme in the shikimate pathway, transferring the enolpyruvyl group of phosphoenolpyruvate to shikimate-3-phosphate to form 5-enolpyruvyl-3-shikimate phosphate and inorganic phosphate. ...

Chorismate synthase: An attractive target for drug development against orphan diseases

Universidade Estadual Paulista (UNESP); Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) (2007-03-01)

The increase in incidence of infectious diseases worldwide, particularly in developing countries, is worrying. Each year, 14 million people are killed by infectious diseases, mainly HIV/AIDS, respiratory infections, malaria ...

Effects of low doses of polyunsaturated fatty acids on the attention deficit/Hyperactivity disorder of children: A systematic review

Universidade Federal de São Paulo (UNIFESP); Universidade Federal do ABC (UFABC); Universidade Estadual Paulista (UNESP) (2013-04-30)

Since attention deficit/hyperactivity disorder (ADHD) presents high prevalence among children, science has been researching alternative forms of treatment that do not involve medication. Objective: To evaluate the effects ...

Pectin and pectinases: Production, characterization and industrial application of microbial pectinolytic enzymes

Universidade Estadual Paulista (UNESP) (2009-07-21)

Pectinases are a big group of enzymes that break down pectic polysaccharides of plant tissues into simpler molecules like galacturonic acids. It has long been used to increase yields and clarity of fruit juices. Since ...

Annona sp: Plants with multiple applications as alternative medicine - a review

Universidade de Marília (UNIMAR); Faculdade de Tecnologia do Estado de São Paulo (FATEC); Faculdade de Medicina de Marília (FAMEMA); Universidade de São Paulo (USP); Universidade Estadual Paulista (UNESP) (2012-10-08)

Annona species have been used as a natural remedy for a variety of illnesses with antiparasitic, antispasmodic, antidiarrheal, antiulcer, sedative, analgesic, hypotensive, and vermifugal effects. These properties are due ...

Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: A review

Universidade Estadual Paulista (UNESP); Universidade de São Paulo (USP); Metabolic Diseases Institute (2013-04-30)

The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought ...