Buscar
Mostrando ítems 1-10 de 88
Epigenetic regulation of ID4 in breast cancer: Tumor suppressor or oncogene?
(BioMed Central, 2018-08)
Background: Inhibitor of differentiation protein 4 (ID4) is a dominant negative regulator of the basic helix-loop-helix (bHLH) family of transcription factors. During tumorigenesis, ID4 may act as a tumor suppressor or as ...
Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer
(Wiley-liss, Div John Wiley & Sons Inc, 2015-12)
Molecular mechanisms underlying coordinated hypermethylation of multiple CpG islands in cancer remain unclear and studies of methyltransferase enzymes have arrived at conflicting results. We focused on DNMT1 and DNMT3B, ...
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.
(MDPI, 2018-07)
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.Gottifredi V1, Wiesmüller L2.The tumor suppressor p53 is a transcriptional factor broadly mutated in cancer. Most inactivating and gain ...
Bases moleculares del cáncer colorrectalMolecular bases of colorectal cancer
(Universidad de Antioquia, Facultad de MedicinaMedellín, Colombia, 2019)
Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression
(Public Library of Science, 2014-05)
The DOK1 tumor suppressor gene encodes an adapter protein that acts as a negative regulator of several signaling pathways. We have previously reported that DOK1 expression is up-regulated upon cellular stress, via the ...
Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations
(SciTechnol, 2015-02)
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina. It may occur as unilateral, bilateral or rarely as multicentric ...