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Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer
(2013)
Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their ...
High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans
(BIOMED Central Ltd., 2017)
Background: Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) ...
Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes Identificación de asociaciones clínico-patológicas e hipermetilación de genes supresores de tumor
(2007)
Background: Methylation is an inactivation mechanism for tumor suppressor genes, that can have important clinical implications. Aim: To analyze the methylation status of 11 tumor suppressor genes in pathological samples ...
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ Channels
(Nature Publishing Group, 2016)
The DLG-MAGUK subfamily of proteins plays a role on the recycling and clustering of glutamate receptors (GLUR) at the postsynaptic density. discs-large1 (dlg) is the only DLG-MAGUK gene in Drosophila and originates two ...
Tumor Suppression and Promotion by Autophagy
(Hindawi, 2014)
Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly
mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems ...
The reprimo-like gene is an epigenetic-mediated tumor suppressor and a candidate biomarker for the non-invasive detection of gastric cancer
(MDPI, 2020)
Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML ...
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
(Biomed Central Ltd., 2017)
Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
Curcumin rescues breast cells from epithelial‑mesenchymal transition and invasion induced by anti‑miR‑34a
(Spandidos Publications, 2020)
Breast cancer is the most prevalent type of cancer among women worldwide and it is characterized by a high morbidity. Curcumin is a naturally occurring compound derived from the rhizome of Curcuma longa and is known to ...