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Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome
(Frontiers Media S.A., 2018)
Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside
(Elsevier Science, 2019-02)
GM2-gangliosidosis, a subgroup of lysosomal storage disorders, is caused by deficiency of hexosaminidase activity, and comprises the closely related Tay-Sachs and Sandhoff diseases. The enzyme deficiency prevents normal ...
Calcineurin β protects brain after injury by activating the unfolded protein response
(Academic Press Inc Elsevier Science, 2016-10)
The Ca2 +-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with ...
Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity
(2019)
Diabesity is an abnormal metabolic condition shown by patients with obesity that develop type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced vascular response to insulin, and vascular ...
Endoplasmic reticulum chaperone glucose-regulated protein 94 is essential for proinsulin handling
(American Diabetes Association, 2019-04)
Although endoplasmic reticulum (ER) chaperone binding to mutant proinsulin has been reported, the role of protein chaperones in the handling of wild-type proinsulin is underinvestigated. Here, we have explored the importance ...
Chaperone Insufficiency Links TLR4 Protein Signaling to Endoplasmic Reticulum Stress
(Amer Soc Biochemistry Molecular Biology IncBethesdaEUA, 2012)
ENDOPLASMIC RETICULUM STRESS IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS FROM PRE-GESTATIONAL MATERNAL OBESITY
(2017)
Pre-gestational maternal obesity (PGMO) is associated with adverse car-dio-metabolic newborn outcome. Our previous results show insulin-desensitization in human umbilical vein endothelial cells (HUVECs) fromPGMO. The ...
Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production
(Elsevier Science Inc, 2016-10)
StarD7 is an intracellular lipid transport protein identified as up-regulated in the choriocarcinoma JEG-3 cell line. StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown ...