Buscar
Mostrando ítems 1-10 de 149
Macroautophagy and the oncogene-induced senescence
(Frontiers, 2014-09)
The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been ...
Krüppel-like Factor 6 is required for oxidative and oncogene-induced cellular senescence
(Frontiers Media S.A., 2019-11)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its ...
Krüppel-like factor 6 Is required for oxidative and oncogene-iduced cellular senescence
(Frontiers Media S.A., 2019-11)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its ...
Human papillomavirus DNA and oncogene alterations in colorectal tumors
(Springer, 2010-09)
The aim of the present study is to determine the presence and molecular integrity of high-risk HPV types in colorectal adenocarcinomas and to assess whether viral DNA is related to common proto-oncogene alterations, such ...
Descubrimiento de las propiedades oncogénicas de los antígenos MAGEDiscovering the oncogenic properties of MAGE antigens
(Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica, 2017-12)
Desde su descubrimiento como antígenos en células de melanoma humano, la interpretaciónde las proteínas MAGE (Melanoma Antigen GEnes) ha variado mucho. Se ha pasado de verlascomo moléculas promisorias para desarrollar ...
MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function
(Elsevier Science, 2021-03)
Normal-to-tumor cell transition is accompanied by changes in gene expression and signal transduction that turns the balance toward cancer-cell phenotype, eluding by different mechanisms, the response of tumor-suppressor ...
Working together for the family: Determination of HER oncogene co-amplifications in breast cancer
(Impact Journals, 2020-07)
HER2 is a well-studied tyrosine kinase (TK) membrane receptor which functions as a therapeutic target in invasive ductal breast carcinomas (IDC). The standard of care for the treatment of HER2-positive breast is the antibody ...
Oral contraceptives treatment suppresses proliferation and enhances apoptosis of eutopic endometrial tissue from patients with endometriosis
(Elsevier Science Inc, 2002-12)
To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Prospective study. Thirteen women with untreated ...
Protein stabilization by RSUME accounts for PTTG pituitary tumor abundance and oncogenicity
(BioScientifica, 2018-06)
Increased levels of the proto-oncogene pituitary tumor-transforming gene 1 (PTTG) have been repeatedly reported in several human solid tumors, especially in endocrine-related tumors such as pituitary adenomas. Securin PTTG ...
Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
(Nature Publishing Group, 2008-03)
Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and ...