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KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells
(Public Library of Science, 2019-01)
The process of neuronal differentiation is associated with neurite elongation and membrane biogenesis, and phosphatidylcholine (PtdCho) is the major membrane phospholipid in mammalian cells. During neuroblast differentiation, ...
Minimal disseminated disease evaluation and outcome in trilateral retinoblastoma
(B M J Publishing Group, 2018-11)
Trilateral retinoblastoma (TRb) presents a management challenge, since intracranial tumours are seldom times resectable and quickly disseminate. However, there are no risk factors to predict the final outcome in each ...
Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats
(Elsevier Science, 2019-11-18)
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of ...
Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes
(Academic Press Inc Elsevier Science, 2017-12)
Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairment and dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularly vulnerable. ...
Increased Number of Neurons in the Cervical Spinal Cord of Aged Female Rats
(Public Library of Science, 2011-07)
In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about ...
Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis
(Cell Press, 2017-11)
Engineering of biomaterials with specific biological properties has gained momentum as a means to control stem cell behavior. Here, we address the effect of bifunctionalized hydrogels comprising polylysine (PL) and a 19-mer ...
17α-Oestradiol-induced neuroprotection in the brain of spontaneously hypertensive rats
(Wiley, 2014-04-14)
17β-oestradiol is a powerful neuroprotective factor for the brain abnormalities of spontaneously hypertensive rats (SHR). 17α-Oestradiol, a nonfeminising isomer showing low affinity for oestrogen receptors, is also endowed ...
Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats
(Pergamon-Elsevier Science Ltd, 2015-09)
The hippocampus, a medial temporal lobe structure necessary for the formation of spatial memory, is particularly affected by both normal and pathologic aging. In previous studies, we observed a significant age-related ...