Buscar
Mostrando ítems 1-10 de 61
A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors
(Wiley Blackwell Publishing, Inc, 2021-04)
The α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug ...
Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle
(American Society for Pharmacology and Experimental Therapeutics, 2007-05)
Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter-gated ion channels that mediate synaptic transmission throughout the nervous system in vertebrates and invertebrates. Caenorhabditis elegans is a ...
Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium
(American Society for Pharmacology and Experimental Therapeutics, 2018-11)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in neuromuscular transmission. In nematodes, muscle nAChRs are targets of antiparasitic drugs. Bephenium is an anthelmintic compound whose ...
Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs
(John Wiley & Sons Inc, 2009-12)
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic ...
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Wnt-7a Induces Presynaptic Colocalization of 7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons
(Society for Neuroscience, 2007-05-16)
Nicotinic acetylcholine receptors (nAChRs) contribute significantly to hippocampal function. Alpha7-nAChRs are present in presynaptic sites in hippocampal neurons and may influence transmitter release, but the factors that ...
Relationship between α7 nAChR and apoptosis in human lymphocytes
(Elsevier Science, 2005-03)
The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of a7 nAChR in peripheral human lymphocytes and determined ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015-08)
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be ...
Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2010-05)
Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin selective reuptake inhibitors, on nicotinic acetylcholine receptors ...
α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR
(American Chemical Society, 2006-02)
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and ...