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Aminochrome induces irreversible mitochondrial dysfunction by inducing autophagy dysfunction in Parkinson's disease
(Frontiers Media S.A., 2018)
Brain mitochondrial dysfunction in aging
(John Wiley & Sons Inc., 2008-04)
Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by ...
Mitochondrial mechanisms in septic cardiomyopathy
(MDPI AG, 2015-08)
Sepsis is the manifestation of the immune and inflammatory response to infection that may ultimately result in multi organ failure. Despite the therapeutic strategies that have been used up to now, sepsis and septic shock ...
The shape of mitochondrial dysfunction in Down Syndrome
(John Wiley & Sons Inc, 2019-07)
Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied and defined as therapeutic targets in Down syndrome (DS). Though originally associated to individual genes located in supernumerary ...
Commentary: A humanized clinically calibrated quantitative systems pharmacology model for hypokinetic motor symptoms in Parkinson's disease
(Frontiers Research Foundation, 2016)
The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
(Frontiers Research Foundation, 2014)
A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's ...
MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
(2017)
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in ...
Role of Mitochondrial Dysfunction in Hypertension and Obesity
(Current Medicine Group, 2017-02)
Mitochondria are essential for the maintenance of normal physiological function of tissue cells. Mitochondria are subject to dynamic processes in order to establish a control system related to survival or cell death and ...