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IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats
(Frontiers Research Foundation, 2019-03-05)
Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous ...
Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation
(Wiley-liss, Div John Wiley & Sons Inc, 2007-06)
Microglia, monocytes, and peripheral macrophages share a common origin and many characteristics, but what distinguishes them from each other at the level of gene expression remains largely unknown. In this study, we compared ...
Microglia-precursor cell interactions in health and in pathology
(Instituto de Histología y Embriología "Dr. Mario Burgos", 2018-11)
Until recently, microglia were mainly known as the resident phagocytes of the brain, i.e. the ‘immunological warriors’ of the brain. However, extensive knowledge is being accumulated about the functions of microglia beyond ...
Reactivity of microglia and astrocytes after an excitotoxic injury induced by kainic acid in the rat spinal cord
(Churchill Livingstone, 2019-02)
After injury of the nervous system glial cells react according to the stimuli by modifying their morphology and function. Glia activation was reported in different kainic acid (KA)-induced neurodegeneration models. Here, ...
Differential response of pineal microglia to surgical versus pharmacological stimuli
(Wiley-liss, Div John Wiley & Sons Inc, 2018-10)
Microglial cells are one of the interstitial elements of the pineal gland (PG). We recently reported the pattern of microglia colonization and activation, and microglia-Pax6+ cell interactions during normal pineal ontogeny. ...
Neuroinflammation in Huntington’s Disease: A Starring Role for Astro-cyte and Microglia
(Bentham Science Publishers, 2021-11-26)
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction. Since no existing treatment affects the ...
IGF1 gene therapy reversed cognitive deficits and restored hippocampal alterations after chronic spinal cord injury
(Springer Nature, 2021-12)
The hippocampus is implicated in the generation of memory and learning, processes which involve extensive neuroplasticity. The generation of hippocampal adult-born neurons is particularly regulated by glial cells of the ...
Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro
(Elsevier, 2020-11)
Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the vitreous body protects injured retinal ganglion cells ...
Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles
(Humana Press, 2018-11-24)
Adolescence is a transitional period from childhood to adulthood characterized by puberty and brain maturation involving behavioral changes and environmental vulnerability. Diet is one of the factors affecting brain health, ...
The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia
(Springer/Plenum Publishers, 2007-12)
In order to further characterize the still unknown mechanism of cuprizone-induced demyelination, we investigated its effect on rat primary oligodendroglial cell cultures. Cell viability was not significantly affected by ...