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New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
(Frontiers Media, 2020)
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glycolysis and fatty acid ...
Interferon-γ, interleukins-6 and -4, and factor XIII-A as indirect markers of the classical and alternative macrophage activation pathways in chronic periodontitis
(American Academy of Periodontology, 2014)
Macrophages account for 5% to 30% of the inflammatory infiltrate in periodontitis and are activated by the classic and alternative pathways. These pathways are identified by indirect markers, among which interferon (IFN)-γ ...
Peptides conjugated to gold nanoparticles induce macrophage activation
(2009)
Macrophages that react against pathogenic organisms can also be activated with artificial nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using bone marrow-derived macrophages, here we ...
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
(BioMed Central, 2016)
Background: Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the ...
Productive infection of Piscirickettsia salmonis in macrophages and monocyte-like cells from rainbow trout, a possible survival strategy
(2009)
Piscirickettsia salmonis is the etiologic agent of the salmonid rickettsial septicemia (SRS), an endemic disease which causes significant losses
in salmon production. This intracellular bacterium is normally cultured in ...
Macrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line
(2016)
© 2016 Wiley Periodicals, Inc. In vertebrates, damage to mechanosensory hair cells elicits an inflammatory response, including rapid recruitment of macrophages and neutrophils. While hair cells in amniotes usually become ...
Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF-κB decoy oligodeoxynucleotide
(John Wiley and Sons Inc., 2017)
Excessive production of wear particles from total joint replacements (TJRs) induces chronic
inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This
inflammation and bone remodeling ...
Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4
(American Society of Biochemistry Molecular Biology, 2020)
Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages
(BioMed Central, 2017)
Background: Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis,
S. Typhimurium and S. Gallinarum. However, it is absent in typhoid serovars such as S. Typhi and ...
Lipopolysaccharide from porphyromonas gingivalis, but not from porphyromonas endodontalis, induces macrophage M1 profile
(MDPI, 2022)
Apical Lesions of Endodontic Origin (ALEO) are initiated by polymicrobial endodontic canal infection. Porphyromonas gingivalis (Pg) and Porphyromonas endodontalis (Pe) lipopolysaccharides (LPS) can induce a pro-inflammatory ...