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Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs
(2010-09-01)
Background: Methylprednisolone is one of the most commonly used steroids for management of chronic back pain via epidural injection. Its inadvertent injection into the intrathecal space is associated with complications ...
Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice
(2003)
The nonsteroidal anti-inflammatory drugs (NSAIDs) clonixin, diclofenac, piroxicam, ketoprofen, meloxicam, and paracetamol induced antinociception after intraperitoneal or intrathecal administration in mice submitted to an ...
Role of cGMP and cAMP in the hemodynamic response to intrathecal sildenafil administration
(Faculdade de Medicina / USP, 2011)
INTRODUCTION: Results from our laboratory have demonstrated that intracerebroventricular administration of sildenafil to conscious rats promoted a noticeable increase in both lumbar sympathetic activity and heart rate, ...
A novel method for subarachnoid drug delivery in the medullary region of rats
(Elsevier Science BvAmsterdamHolanda, 2005)
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes
(1999-01-27)
Background and Objectives. The analgesic actions of nonsteroidal anti-inflammatory drugs (NSAID) result from the inhibition of the peripheral synthesis of prostaglandins. In spite of the emphasis on the peripheral action, ...
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron
(NATL ACAD SCIENCES, 2008)
Previous work from our group showed that intrathecal (i.t.) administration of substances such as glutamate, NMDA, or PGE(2) induced sensitization of the primary nociceptive neuron (PNN hypernociception) that was inhibited ...
Carbachol interactions with nonsteroidal anti-inflammatory drugs
(2002)
The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, ...