Buscar
Mostrando ítems 1-10 de 17
Antitumor role of histamine h4 receptor in human t-cell lymphoma: therapeutic benefit for combination therapy with histamine and histone deacetylase inhibitors
(Fundación Revista Medicina, 2019)
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of histamine role in numerous physiological and pathological conditions, including tumor development and progression. High histamine ...
Current knowledge and perspectives on histamine H1 and H2 receptor pharmacology: Functional selectivity, receptor crosstalk, and repositioning of classic histaminergic ligands
(American Society for Pharmacology and Experimental Therapeutics, 2016-11)
H1 and H2 histamine receptor antagonists, although developed many decades ago, are still effective for the treatment of allergic and gastric acid-related conditions. This article focuses on novel aspects of the pharmacology ...
Histaminergic systems of the limbic complex on learning and motivation
(Elsevier Science, 2001-10)
The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic ...
The activation of histamine-sensitive sites of the ventral hippocampus modulates the consolidation of a learned active avoidance response in rats
(Elsevier Science, 2008-05)
Previous evidence from our laboratory has shown that histamine receptors located into the ventral hippocampus modulate learning and memory processes. Stimulation of histamine hippocampal sensitive receptors during the ...
Potential negative effects of anti-histamines on male reproductive function
(BioScientifica, 2018-04)
Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, ...
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer
(Nature Publishing Group, 2020-02)
Background: The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast ...
Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model.
(American Society for Pharmacology and Experimental Therapeutics, 2003-08-01)
Knowing the importance for research and pharmacological uses of proper ligand classification into agonists, inverse agonists, and antagonists, the aim of this work was to study the behavior of tiotidine, a controversial ...
Dual role of histamine in modulation of Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes
(Society for the Study of Reproduction, 2005-11-01)
Although several reports indicate effects of histamine (HA) on female reproductive functions, scant literature exists to suggest a physiological role of HA in the male gonad. In the present study, we report a dual ...
Histamine H4 receptor agonists induce epithelial-mesenchymal transition events and enhance mammosphere formation via Src and TGF-β signaling in breast cancer cells
(Pergamon-Elsevier Science Ltd, 2020-10)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer ...
Pharmacological targeting of histamine H4 receptor in periodontal disease
(Wiley Blackwell Publishing, Inc, 2016-02)
Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in ...