Buscar
Mostrando ítems 1-10 de 332
Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation
(American Society for Clinical Investigation, 2020)
The blood hormone erythropoietin (EPO), upon binding to its receptor (EpoR), modulates high-fat diet-induced (HFO-induced) obesity in mice, improves glucose tolerance, and prevents white adipose tissue inflammation. ...
Neutral lipids as early biomarkers of cellular fate: the case of α-synuclein overexpression
(Springer, 2021-01-07)
α-synuclein (α-syn) accumulation and aggregation is a common pathological factor found in synucleinopathies, a group of neurodegenerative disorders that includes Parkinson´s disease (PD). It has been proposed that lipid ...
Enhanced in vitro drought tolerance of solanum tuberosum and solanum commersonii plants overexpressing the sccbf1 geneCIENCIA E INVESTIGACION AGRARIACIENC INVESTIG AGRAR
(PONTIFICIA UNIV CATOLICA CHILE, FAC AGRONOMIA INGENIERIA FORESTAL, 2016)
Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis)
(Elsevier, 2015)
So far, typical causes of presbycusis such as degeneration of hair cells and/or primary auditory (spiral ganglion) neurons cannot be treated. Because erythropoietin's (Epo) neuroprotective potential has been shown previously, ...
Overexpression of Arabidopsis aspartic protease APA1 gene confers drought tolerance
(Elsevier Ireland, 2020-03)
Drought is an environmental stress that severely affects plant growth and crop production. Different studies have focused on drought responses but the molecular bases that regulate these mechanisms are still unclear. We ...
Overexpression of snakin-1 gene enhances resistance to Rhizoctonia solani and Erwinia carotovora in transgenic potato plants
(Wiley-Blackwell, 2008-05)
Snakin‐1 (SN1), a cysteine‐rich peptide with broad‐spectrum antimicrobial activity in vitro, was evaluated for its ability to confer resistance to pathogens in transgenic potatoes. Genetic variants of this gene were cloned ...
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated
(Karger, 2016-05)
Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, ...
Over-expression of SINAL7 increases biomass and drought tolerance, and also delays senescence in Arabidopsis
(Elsevier Science, 2018-10)
The seven in absentia like 7 gene (At5g37890, SINAL7) from Arabidopsis thaliana encodes a RING finger protein belonging to the SINA superfamily that possesses E3 ubiquitin-ligase activity. SINAL7 has the ability to ...
Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis
(Public Library of Science, 2021)
BACKGROUND: The parasite Taenia solium causes neurocysticercosis (NCC) in humans and is a common cause of adult-onset epilepsy in the developing world. Hippocampal atrophy, which occurs far from the cyst, is an emerging ...
Constitutive overexpression of EPSPS by gene duplication is involved in glyphosate resistance in Salsola tragus
(Wiley, 2022-11)
Background: Glyphosate-resistant Salsola tragus accessions have been identified in the USA and Argentina; however, the mechanisms of glyphosate resistance have not been elucidated. The goal of this study was to determine ...