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Media interaction and stability of a gamma irradiated albumin nanoparticle
(Elsevier, 2019-12-20)
Protein nanoparticle designing at the nanoscale is challenging because of protein vulnerability to chemical and physical degradation during processing and biodistribution. We present a crosslinked gamma irradiated albumin-based ...
Effect of chemotherapeutic drugs on telomere length and telomerase activity
(Smart Science & Technology, 2016-12)
Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites ...
Two different thiosemicarbazone tauto-conformers coordinate to Palladium (II): Stability and biological studies of the final complexes
(Wiley VCH Verlag, 2021-03-19)
Thiosemicarbazone moiety is a valuable scaffold for the synthesis of metallic complexes with anticancer purposes, when bearing N-heterocyclic the final compounds possess diverse biological activities. Using thiazole as ...
Estudios de incompatibilidad química del alprazolam con excipientes usados en la preparación de comprimidosChemical incompatibility studies of alprazolam with excipients used in tablet formulations
(Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasGrupo de Estabilidad de Medicamentos, Cosméticos y Alimentos (GEMCA)Medellín, Colombia, 2021)
Furosemide:Triethanolamine Salt as a Strategy to Improve the Biopharmaceutical Properties and Photostability of the Drug
(American Chemical Society, 2019-04)
With the purpose of enhancing the biopharmaceutical properties of the furosemide, a pharmaceutical salt was obtained and characterized by combining the drug and triethanolamine. The solid system was prepared using different ...
Factores que afectan la estabilidad de alprazolam. Elucidación estructural de los principales productos de degradaciónFactors affecting the stability of alprazolam structure elucidation of the major degradants
(Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasGrupo de Estabilidad de Medicamentos, Cosméticos y Alimentos (GEMCA)Medellín, Colombia, 2021)
Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds
(Elsevier, 2014)
Recombinant wild-pyrazinamidase from H37Rv Mycobacterium tuberculosis was analyzed by gel electrophoresis under differential reducing conditions to evaluate its quaternary structure. PZAse was fractionated by size exclusion ...
Análisis de la temperatura propuesta por la conferencia internacional sobre armonización (ICH) para Colombia en los estudios de estabilidad natural de medicamentosAnalisis of the temperature proposed by the international conference of harmonization (ICH) for Colombia in the long term stability studies of drugs
(Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasDiseño y Formulación de Medicamentos Cosméticos y AfinesMedellín, Colombia, 2021)
Stress testing of valsartan: Development and validation of a high performance liquid chromatography stability-indicating assay
(Taylor & Francis, 2012-04)
Stress testing studies were carried out on Valsartan (VAL) under hydrolytic (acidic, basic, and neutral), photolytic, oxidative, and thermal (in the solid state) conditions. Relevant degradation was observed when the drug ...
Azithromycin loaded on hydrogels of carbomer: Chemical stability and delivery properties
(Elsevier Science, 2009-01)
Hydrogels of carbomer (C) and azithromycin (AZI) were prepared by neutralizing with AZI 50% of the carboxylic groups of 0.25% C974 and C934 dispersions. The hydrogels exhibit pH close to 8 and are physically stable. Titration ...