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The effects of oral glutamine on cisplatin-induced nephrotoxicity in rats
(Elsevier B.V., 2003-06-01)
The antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative damage in rat kidney and nephrotoxicity induced by the treatment with a single dose of the antitumoral cisplatin ...
Serum magnesium levels in healthy dogs submitted to the administration of cisplatin with fluid therapy
(Univ Nacional Autonoma Mexico Facultad Medicina Veterinaria Zootecnia, 2011-01-01)
Cisplatin is an antineoplastic drug that is used to treat carcinomas and osteosarcomas in dogs. However, it can cause kidney damage which in turn leads to the loss of electrolytes. Concentration of magnesium was evaluated ...
Amifostine protective effect on cisplatin-treated rat testis
(Wiley-liss, 2008-07-01)
Cisplatin is a potent drug used in clinical oncology but causes spermatogenesis damage. Amifostine is a drug used against toxicity caused by ionizing irradiation and chemotherapeutic drugs. Since cisplatin provokes fertility ...
Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy?
(Frontiers Media S.A., 2014)
© 2014 Roco, Cayún, Contreras, Stojanova and Quiñones.Several recent pharmacogenetic studies have investigated the variability in both outcome and toxicity in cisplatin-based therapies. These studies have focused on the ...
Organic anion transporter 5 (Oat5) renal expression and urinary excretion in rats treated with cisplatin: a potential biomarker of cisplatin-induced nephrotoxicity
(Springer, 2013-05)
Cisplatin is one of the most potent chemotherapeutic antitumor drugs used in the treatment of a wide range of solid tumors. Its primary dose-limiting side effect is nephrotoxicity. The organic anion transporter 5 (Oat5) ...
Protective effect of bixin on cisplatin-induced genotoxicity in PC12 cells
(Pergamon-Elsevier B.V. Ltd, 2012-02-01)
Bixin is the main carotenoid found in annatto seeds (Bixa orellana L.) and is responsible for their reddish-orange color. The antioxidant properties of this compound are associated with its ability to scavenge free radicals, ...
The effects of oral glutamine on cisplatin-induced genotoxicity in Wistar rat bone marrow cells
(Elsevier B.V., 2002-06-27)
Several studies have suggested that dietary supplementation with antioxidants can influence the response to chemotherapy as well as the development of adverse side effects that result from treatment with antineoplastic ...
Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin
(Funpec-editora, 2013-01-01)
Cisplatin is an effective antineoplastic drug. However, it provokes considerable collateral effects, including genotoxic and clastogenic activity. It has been reported that a diet rich in glutamine can help inhibit such ...