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Effects of third generation beta-blockers, atenolol or amlodipine on blood pressure variability and target organ damage in spontaneously hypertensive rats
(Lippincott Williams, 2020-03)
Background: b-blockers are no longer considered as firstline antihypertensive drugs due to their lower cardioprotection. Method: Considering the differences in the pharmacological properties of b-blockers, the present work ...
Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats
(Elsevier Science, 2006-08)
NADPH oxidase is critically involved in increased blood pressure, vascular hypertrophy, inflammation and endothelial dysfunction in experimental and clinical hypertension. We hypothesized that NADPH oxidase might also play ...
Morphological alterations in skeletal muscle of spontaneously hyperensive rats
(Universidad del Zulia, 2013)
Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study
(Springer, 2006-05)
The present work addressed possible alterations inthe pharmacokinetics and the in vivo pharmacodynamic ofmetoprolol (MET) in spontaneously hypertensive (SH) ratsand Wistar Kyoto (WKY) animals by means of the microdialysi ...
Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
(Elsevier Science, 2004-09-22)
We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant ...
Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
(Elsevier Ireland, 2014-03)
Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously ...
Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
(Wiley Blackwell Publishing, Inc, 2020-01-13)
Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting ...
Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
(Elsevier Science, 2015-01)
The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood ...
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
(Oxford University Press, 2006-12)
Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences ...
17α-Oestradiol-induced neuroprotection in the brain of spontaneously hypertensive rats
(Wiley, 2014-04-14)
17β-oestradiol is a powerful neuroprotective factor for the brain abnormalities of spontaneously hypertensive rats (SHR). 17α-Oestradiol, a nonfeminising isomer showing low affinity for oestrogen receptors, is also endowed ...