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Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen Expression
(Frontiers Media, 2021-11)
Hepatitis B virus (HBV) inter-host evolution has resulted in genomic diversification reflected in the existence of nine genotypes (A-I) and numerous subgenotypes. There is growing evidence that genotypes influence HBV ...
Long‐term evolution of hepatitis B virus genotype F: strong association between viral diversification and the prehistoric settlement of Central and South America
(Wiley Blackwell Publishing, Inc, 2020-02)
The genotype F (HBV-F) is an autochthonous Native American strain of the hepatitis B virus. In this study, we reconstruct the HBV-F long-term evolution under a hypothesis of co-divergence with humans in Central and South ...
Hantavirus Pulmonary Syndrome in Tucumán province associated to an unexpected viral genotype
(Medicina (Buenos Aires), 2017-05)
We describe the characterization of the viral genotype involved in the first case of hantavirus pul-monary syndrome reported in Tucumán, a Northwestern province of Argentina. A 23-year-old woman, with no record of travel ...
A model to predict the response to therapy against hepatitis C virus (HCV) including low-density lipoprotein receptor genotype in HIV/HCV-coinfected patients
(Oxford University Press, 2012-12-12)
Accurate prediction of sustained virological response (SVR) to pegylated interferon-a (Peg-IFN) plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients could improve the management of these patients. We aimed to ...
A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity
(Elsevier, 2018-07-19)
Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the ...
Analysis of fitness differences of hepatitis B virus genotypes D and F using a cotransfection assay
(Springer Wien, 2019-02)
Hepatitis B virus (HBV) circulates as a collection of genetically related variants that evolve throughout the chronic infection. Those viral variants that have the greatest ftness are fxed. We recently showed diferent ...
Enteric Viruses in Surface Waters from Argentina: Molecular and Viable-Virus Detection
(American Society for Microbiology, 2018-02)
Water resources contaminated with wastewater are an important source for the dissemination of enteric viruses with an impact on the health of the population. The aim of the study was to assess the viral contamination of ...
Sixteen years of evolution of human respiratory syncytial virus subgroup A in Buenos Aires, Argentina: GA2 the prevalent genotype through the years
(Elsevier Science, 2016-06)
Human respiratory syncytial virus (HRSV) is the main viral cause of acute lower respiratory tract infections (LRTI) in children worldwide. In recent years, several preclinical trials with vaccine candidates have been ...
Impact of hepatitis B virus genotype F on in vitro diagnosis: detection efficiency of HBsAg from Amerindian subgenotypes F1b and F4
(Springer Wien, 2019-09)
The influence of the high genetic variability of hepatitis B virus (HBV) on the sensitivity of serological assays has received little attention so far. A major source of variability is related to viral genotypes and ...