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Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
(2006)
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...
Cerebral vasodilators Vasodilatadores cerebrales.
(1990)
Cerebral vasodilators (CVD) account for 1.6% of the annual expenditure on drugs in Chile. Two kinds are typified: what we have called orthodox CVD and calcium-channel blockers. They have two main uses in neurology: firstly, ...
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
(2016)
The vascular endotheliumplays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a ...
Survival of patients with pulmonary arterial hypertension after the advent of specific pulmonary vasodilator therapies
(Soc. Médica Santiago, 2016)
Background: Pulmonary arterial hypertension (PAH) is a rare and progressive disease. Long-term survival remains poor despite of advances in specific vasodilator therapy. Aim: To describe the survival rate in a cohort of ...
Plasma nitrate levels and flow-mediated vasodilation in untreated
(2011-05)
Objective: Findings from several studies have revealed that major depression is associated with an increased cardiovascular risk. The physiopathologic mechanisms of this association remain unclear, although recently, it ...
Efecto del polimorfismo del receptor b2 adrenérgico sobre la respuesta antihipertensiva en pacientes con hipertensión esencial
(Universidad de Antioquia, Facultad de MedicinaBiología Celular y Molecular CIB U. de A. U. del RosarioMedellín, Colombia, 2023)
Reduced Cystathionine g-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies Hydrogen Sulfide as a Placental Vasodilator
(Elsevier, 2013)
Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth
restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in ...
Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease
(Nature, 2016)
Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions
(Academic Press Inc., 2019)
Nitric oxide (NO) is the main vasodilator agent that drives the rapid decrease of pulmonary vascular resistance for the respiratory onset during the fetal to neonatal transition. Nevertheless, the enhanced NO generation ...