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Functional multimerization of mucolipin channel proteins
(Wiley, 2010-02)
MCOLN1 encodes mucolipin-1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis-type IV (MLIV), a lysosomal storage disorder characterized by ...
Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages
(Rockefeller University Press, 2020)
Phagocytes use their actomyosin cytoskeleton to migrate as well as to probe their environment by phagocytosis or macropinocytosis. Although migration and extracellular material uptake have been shown to be coupled in some ...
TRPML regula la migración y fagocitosis en hemocitos de Drosophila melanogaster mediante la liberación localizada de calcio desde los lisosomas
(2019-01)
Lysosomal physiology has been shown to be important for the correct functioning of immune cells, including their migratory and their phagocytic properties. In this work, we aimed to explore the migratory process of immune ...
Differential regulation of TRP channels in a rat model of neuropathic pain
(ELSEVIER SCIENCE BV, 2009)
Neuropathic pain is a chronic disease resulting from dysfunction of the nervous system often due to peripheral nerve injury. Hypersensitivity to sensory Stimuli (mechanical, thermal or chemical) is a common source of pain ...