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Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior
(Future Medicine Ltd., 2018-09)
Solid dispersions using Poloxamer 407 as carrier were developed to improvealbendazole (ABZ) solubility and dissolution profiles. ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically ...
Improving the dissolution of Triclabendazole from stable crystalline solid dispersions formulated for oral delivery
(Springer, 2020-01)
Triclabendazole belongs to the class II/IV of the Biopharmaceuticals Classification System, and its low aqueous solubility represents a major drawback during the development of effective dosage forms. Therefore, the goal ...
Structural Elucidation of Poloxamer 237 and Poloxamer 237/Praziquantel Solid Dispersions: Impact of Poly(Vinylpyrrolidone) over Drug Recrystallization and Dissolution
(Springer, 2018-04)
Praziquantel (PZQ) is the recommended, effective, and safe treatment against all forms of schistosomiasis. Solid dispersions (SDs) in water-soluble polymers have been reported to increase solubility and bioavailability of ...
Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug
(Cambridge University Press, 2020-04)
Alveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis. The pharmacological treatment is based on albendazole (ABZ). However, the low water solubility of the drug produces a limited ...
New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement
(International Pharmaceutical Excipients Council of the Americas, 2012-12)
Solid dispersions (SDx) containing Indomethacin (IND), a poorly water-soluble drug,and the disintegrant excipient sodium croscarmellose (SC) were prepared by a co-drying method and characterized by FT-IR, X-ray diffraction ...
The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components
(Springer, 2018-03-16)
Purpose: Solid dispersions (SDs) of a poorly water-soluble drug were prepared, and their physicochemical properties were compared to those of control physical mixtures (PMs). Among the multiple techniques used to characterize ...
Very fast dissolving acid carboxymethylcellulose-rifampicin matrix: development and solid-state characterization
(Elsevier Science, 2016-10)
One of the main obstacles to the successful treatment of tuberculosis is the poor and variable oral bioavailability of rifampicin (RIF), which is mainly due to its low hydrophilicity and dissolution rate. The aim of this ...
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection
(American Society of Parasitologists, 2020-05-04)
Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, ...
Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance
(Elsevier, 2018-11)
Benznidazole (BZL), the first line drug for Chagas disease treatment, presents a low solubility, limiting the possibilities for its formulation. In this work, solid dispersions’ (SDs) technology was exploited to increase ...
Matrix solid-phase dispersion: a simple and fast technique for the determination of phenolic compounds in olive oil by liquid chromatography
(Royal Society of Chemistry, 2014-10)
A methodology was developed using matrix solid phase dispersion, together with liquid chromatography with multiple wavelength detector for the determination of twenty phenolic compounds in olive oil samples. Under optimized ...