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Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
(2002)
The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of the transcription of genes that encode these channels occurs during early neuronal development. ...
Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating properties
(1989)
Squid optic nerve sodium channels were characterized in planar bilayers in the presence of batrachotoxin (BTX). The channel exhibits a conductance of 20 pS in symmetrical 200 mM NaCI and behaves as a sodium electrode. The ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Sociedade Brasileira de Química, 2008-01-01)
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the ...
A new class of neurotoxin from wasp venom slows inactivation of sodium current
(Blackwell Science, 2000-06-01)
The effects of alpha-pompilidotoxin (alpha-PMTX), a new neurotoxin isolated from the venom of a solitary wasp, were studied on the neuromuscular synapses in lobster walking leg and the rat trigeminal ganglion (TG) neurons. ...
Effects of beta-adrenoceptor antagonists in the neural nitric oxide release induced by electrical field stimulation and sodium channel activators in the rabbit corpus cavemosum
(Elsevier Science BvAmsterdamHolanda, 2005)