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The Na+/glucose cotransporters: from genes to therapy
(Associação Brasileira de Divulgação Científica, 2010)
Glucose enters eukaryotic cells via two types of membrane-associated carrier proteins, the Na+/glucose cotransporters (SGLT) and the facilitative glucose transporters (GLUT). The SGLT family consists of six members. Among ...
Ghrelin Facilitates GLUT2-, SGLT1-and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus)
(Nature Publishing Group, 2017-03)
Glucose homeostasis is an important biological process that involves a variety of regulatory mechanisms. This study aimed to determine whether ghrelin, a multifunctional gut-brain hormone, modulates intestinal glucose ...
Sodium‑glucose cotransporter 2 inhibitors (SGLT2i): renal implications
(Springer, 2020)
Type 2 diabetes mellitus (DM2) is a chronic condition that affects more than 400 million individuals worldwide. In DM2 patients, an appropriate glycemic control slows the onset and delays the progression of all its micro ...
Inhibidores del cotransportador de sodio-glucosa tipo 2: Efecto de los mecanismos moleculares en el miocardio
(Asociación Costarricense de Cardiología, 2021)
Na plus -Glucose Cotransporter SGLT1 Protein in Salivary Glands: Potential Involvement in the Diabetes-Induced Decrease in Salivary Flow
(SPRINGER, 2009)
Oral health complications in diabetes include decreased salivary secretion. The SLC5A1 gene encodes the Na(+)-glucose cotransporter SGLT1 protein, which not only transports glucose, but also acts as a water channel. Since ...
Inhibidores de SGLT-2 en Nefropatía Lúpica. Podria considerarse una intervención de Nefroprotección
(Sociedad Paraguaya de Reumatología, 2022)
SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation
(Nature Publishing Group, 2016)
High glucose concentration in the airway surface liquid (ASL) is an important feature of diabetes that predisposes to respiratory infections. We investigated the role of alveolar epithelial SGLT1 activity on ASL glucose ...
Identification and assessment of glucose transporters SGLT1 and GLUT2 and incretin GLP-1 in the small intestine of guinea pigs (cavia porcellus)IDENTIFICACIÓN Y EVALUACIÓN DE TRANSPORTADORES DE GLUCOSA SGLT1 Y GLUT2 Y LA INCRETINA GLP-1 EN INTESTINO DELGADO DE CUYES (Cavia porcellus).
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2012)
Efficacy and Safety of the Use of SGLT2 Inhibitors in Patients on Incremental Hemodialysis: Maximizing Residual Renal Function, Is There a Role for SGLT2 Inhibitors?
(MDPI, 2023)
SGLT-2i are the new standard of care for diabetic kidney disease (DKD), but previous studies have not included patients on kidney replacement therapy (KRT). Due to their high risk of cardiovascular, renal complications, ...
Yerba Maté (Ilex paraguariensis) aqueous extract decreases intestinal SGLT1 gene expression but does not affect other biochemical parameters in alloxan-diabetic wistar rats
(Davis, 2008)
Yerba mate´ (Ilex paraguariensis) is rich in polyphenols, especially chlorogenic acids. Evidence suggests that dietary polyphenols could play a role in glucose absorption and metabolism. The aim of this study was to evaluate ...