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Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2001-05)
Although the dissociative anesthetic dizocilpine [(+)-MK-801] inhibits nicotinic acetylcholine receptor (AChR) function in a noncompetitive manner, the location of the dizocilpine binding site(s) has yet to be clearly ...
Extracellular Signaling Receptors
(Springer, 2009)
Classically, receptors were defined as cellular structures that recognize and bind hormones. In present days this definition is expanded to include receptors for a variety of other extracellular regulatory signaling ...
Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2010-05)
Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin selective reuptake inhibitors, on nicotinic acetylcholine receptors ...
Interaction of Barbiturate Analogs with the Torpedo californica Nicotinic Acetylcholine Receptor Ion Channel
(American Society for Pharmacology and Experimental Therapeutics, 2001-09)
Barbiturate-induced anesthesia is a complex mechanism that probably involves several ligand-gated ion channel superfamilies. One of these superfamilies includes the archetypical nicotinic acetylcholine receptor (nAChR), ...
Noncompetitive antagonist binding sites in the Torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives
(American Chemical Society, 2003-06)
We used a series of adamantane derivatives to probe the structure of the phencyclidine locus in either the resting or desensitized state of the nicotinic acetylcholine receptor (AChR). Competitive radioligand binding and ...
THE USE OF COMPETlTlVE LIGAND BINDING RESULTS IN QSAR STUDIES
(Elsevier, 1984-06-28)
The use in QSAR studies of parameters measuring the
ability of an unlabeled rnolecule to compete for the binding site with a
. radioligand is examined.
1t is shown that in order to employ them within a recently ...
Melatonin and testicular function: Characterization of binding sites for 2-[125I]-iodomelatonin in immature rat testes
(Elsevier Inc., 1997)
Melatonin-binding sites in membrane preparation of immature rat testes were demonstrated by utilizing 2-[125I]-iodomelatonin as a radioligand. Binding at these sites was found to be reversible, saturable, specific and of, ...
Effects of unilateral decortication on β-adrenergic receptors in the remaining cortex and in the hypothalamus of female rats
(1986-01-01)
Many experiments have been performed to evaluate the physiological role of catecholaminergic mechanisms of gonadotropin release. The purpose of the present study was to determine the concentration of β-adrenoreceptors in ...