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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins
(MDPI, 2015)
Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located ...
Reação metabólica à infecção no hospedeiro.
(1992-05-01)
At the site of local reaction to infection the interleukin-1 (1L-1) is released signaling to distant tissues the presence of infection and attempting to strengthen the host's defenses and inhibit the bacterial growth. This ...
Macromolecular biosynthetic parameters and metabolic profile in different life stages of Leishmania braziliensis: Amastigotes as a functionally less active stage
(Public Library of Science, 2017)
It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana ...
Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
(Blackwell Publishing Inc., 2019)
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease
(Taylor and Francis, 2016)
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...
Knots can impair protein degradation by ATP-dependent proteases
(National Academy of Sciences, 2017)
ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized ...
Reação metabólica à infecção no hospedeiro.
(1992-05-01)
At the site of local reaction to infection the interleukin-1 (1L-1) is released signaling to distant tissues the presence of infection and attempting to strengthen the host's defenses and inhibit the bacterial growth. This ...