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Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials
(Elsevier Science, 2019-02-10)
Olanzapine (OLZ), a drug for the treatment of schizophrenia, presents in more than 60 crystal forms. Polymorphs I, II and III were reported, however, the preparation conditions for pure II and III have not been reported. ...
A comprehensive approach toward concomitant triclabendazole polymorphism in pharmaceutical products
(Elsevier, 2021-04)
Triclabendazole (TCB) is a highly effective and low-cost anti-parasitic active pharmaceutical ingredient (API) used in the treatment of fascioliasis, a neglected tropical disease caused by Fasciola hepatica. It belongs to ...
Extensive polymorphism at the Gp63 locus in field isolates of Leishmania peruviana
(Elsevier, 1995)
Genetic diversity within and between tandemly arrayed copies of the Gp63 gene occurs in laboratory isolates of Leishmania spp., but the extent to which this represents natural genetic diversity has not been assessed. Here, ...
Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon
(American Society of Tropical Medicine and Hygiene, 2013)
To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α ...
Kappa-casein gene study with molecular markers in female buffaloes (Bubalus bubalis)
(Sociedade Brasileira de GenéticaGrupo de Investigación en Agrociencias Biodiversidad y Territorio GAMMASao Paulo, Brasil, 2023)
Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients
(American Society for Microbiology, 2020)
Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. ...
Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1
(Wiley, 2019)
BACKGROUND: Guillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17, and/or ICAM1 had been proposed as ...
Impact of A118G polymorphism on the Mu opioid receptor function in pain
(OMICS Publishing Group, 2013-07-07)
Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by OPRM1 gene and its messenger RNA ...
Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica
(Universidad de Costa Rica, 2006)
Dissolution properties, solid-state transformation and polymorphic crystallization: Progesterone case study
(Taylor & Francis, 2014-11)
Progesterone is a natural steroid hormone and a poor soluble drug which presents two polymorphs (forms 1 and 2). Different methods to obtain form 2 were tested and a complete solid-state characterization of both polymorphs ...