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PGP source code and internals
(MIT Press, 1995)
Transcriptional Activation by an URE4-like Sequence in the EhPgp1 Gene Core Promoter
(2012)
EhPgp1 is one of the multidrug resistance genes expressed in drug resistant trophozoites from Entamoeba
histolytica. Previous studies in our laboratory have demonstrated that two C/EBP sites participate in the ...
Convulsive Stress Mimics Brain Hypoxia and Promotes the P-Glycoprotein (P-gp) and Erythropoietin Receptor Overexpression. Recombinant Human Erythropoietin Effect on P-gp Activity
(Frontiers Media S.A., 2019-07)
Erythropoietin (EPO) is not only a hormone that promotes erythropoiesis but also has a neuroprotective effect on neurons attributed to its known anti-apoptotic action. Previously, our group has demonstrated that recombinant-human ...
Regulation of hepatic P-gp expression and activity by genistein in rats
(Springer, 2020-03)
P-glycoprotein (P-gp) is an ABC transporter exhibiting high pharmacotoxicological relevance by extruding a wide range of cytotoxic compounds out of the cells. Previously, we demonstrated that the phytoestrogen genistein ...
Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions
P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug-resistant cancer cell lines. In this study, we investigated whether ...
Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp
(Nature Publishing Group, 2021-08)
P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among ...
Formação inicial e continuada de professores: das licenciaturas à constituição de pequenos grupos de pesquisas como associações livres
(Faculdade de Educação da Universidade Federal de Minas Gerais, 2017)
ABSTRACT: We sought to develop aspects of the research that focused on the monitoring of a group of teachers in what we called Small Research Groups (PGP) in public high schools. This accompaniment provided elements that ...
P-glycoprotein expression and pharmacological modulation in larval stages of Echinococcus granulosus
(Elsevier Ireland, 2014-02)
P-glycoprotein (Pgp) is an ATP-dependent transporter involved in the efflux of a wide variety of lipophilic substrates, such as toxins and xenobiotics, out of cells. Pgp expression level is associated with the ineffective ...