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Molecular modeling of the α9α10 nicotinic acetylcholine receptor subtype
(2009)
This study reports the comparative molecular modeling, docking and dynamic simulations of human α9α10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and α-conotoxin RgIA, using as templates the ...
Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation
(John Wiley & Sons A/S, 2012-02-04)
Background and Objective: Several studies have analysed the role of nicotine as a
prominent agent affecting wound repair in smokers. However, tobacco smoke
contains several components that may alter gingival wound healing. ...
Molecular modeling of the a9a10 nicotinic acetylcholine receptor subtype
(Elsevier Ltd., 2008-10-25)
This study reports the comparative molecular modeling, docking and dynamic simulations of human
a9a10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and a-conotoxin RgIA,
using as templates the ...
Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body
(2012)
The carotid bodies (CBs) are chemosensory organs that respond to hypoxemia with transmitter neurosecretion, leading to a respiratory reflex response. It has been proposed that acetylcholine is a key regulator of transmitter ...
Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats
(ELSEVIER, 2010)
Nicotinic acetylcholine receptors influence striatal dopaminergic activity and its outcome on motor behavior.
For these reasons, nicotinic receptors have been considered as therapeutically relevant targets for
Parkinson's ...
Nicotinic antagonist UFR2709 inhibits nicotine reward and decreases anxiety in zebrafish
(MDPI, 2020)
Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery,
mainly due to its ease of handling and low costs involved in maintenance and experimental work.
This animal displays a series of complex ...
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine
(Blackwell Publishing Ltd, 2018)
© 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
The Alteration of Neonatal Raphe Neurons by Prenatal- Perinatal Nicotine Meaning for Sudden Infant Death Syndrome
(Amer. Thoracic. Soc., 2015)
Nicotine may link maternal cigarette smoking with respiratory dysfunctions in sudden infant death
syndrome (SIDS). Prenatal-perinatal nicotine exposure blunts ventilatory responses to hypercapnia
and reduces central ...
Nicotine in the hair of mummies from San Pedro de Atacama (Northern Chile)
(Academic Press, 2013)
The consumption of plant-derived hallucinogenic substances through smoking and snuffing is a long-standing tradition in the south-central Andes. Chemical and archaeobotanical evidence point to the consumption of nicotine ...
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
(ELSEVIER SCI LTD, 2005-12)
S-Nicotine, the principal psychoactive constituent of Nicotiana tabacum, underpins addiction to tobacco smoking. Although tobacco consumption is a leading cause of death worldwide, nicotine itself is also proposed to have ...