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Neuropathologic Heterogeneity in HDDD1: A Familial Frontotemporal Lobar Degeneration With Ubiquitin-positive Inclusions and Progranulin Mutation
(Lippincott Williams & Wilkins, 2007-03)
Hereditary dysphasic disinhibition dementia (HDDD)
describes a familial disorder characterized by personality
changes, and language and memory deficits. The neuropathology
includes frontotemporal lobar atrophy, neuronal ...
Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living
(Dr. Dietrich Steinkopff Verlag GmbH and Co. KG, 2019)
Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social ...
TRP channels regulation of Rho GTPases in brain context and diseases
(Frontiers Media, 2020)
Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural ...
Neuromyelitis optic, a necrotizing disease of the Central Nervous System. Report of two cases Neuromielitis óptica: Una enfermedad necrotizante del Sistema Nervioso Central
(1998)
Optic neuromyelitis is characterized by simultaneous or successive necrotizing lesions involving the optic nerves and the spinal cord. We report two females with the disease, aged 30 and 34 years old. In the latter, a ...
The axonal endoplasmic reticulum and protein trafficking: Cellular bootlegging south of the soma
(Elsevier, 2014)
Neurons are responsible for the generation and propagation of electrical impulses, which constitute
the central mechanism of information transfer between the nervous system and internal or external
environments. Neurons ...
Protein folding stress in neurodegenerative diseases: a glimpse into the ER
(CURRENT BIOLOGY LTD, 2011-03)
Several neurodegenerative diseases share common neuropathology, primarily featuring the presence in the brain of abnormal protein inclusions containing specific misfolded proteins. Recent evidence indicates that alteration ...
Cien años de la enfermedad de Alzheimer. La inmunoterapia ¿una esperanza?
(2007)
In 1906 Alois Alzheimer, described the cerebral lesions
characteristic of the disorder that received his name: senile plaques and neurofibrillary tangles.
Alzheimer’s disease (AD) is now, 100 years after, the most prevalent ...
Targeting autophagy in ALS: A complex mission
(Taylor and Francis Inc., 2011)
Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
Cell-free propagation of prion strains
(NATURE PUBLISHING GROUP, 2008-10-08)
Prions are the infectious agents responsible for prion diseases, which appear to be composed exclusively by the misfolded prion protein (PrPSc). Disease is transmitted by the autocatalytic propagation of PrPSc misfolding ...
Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins
(2007)
The detailed anatomy of the monoamine pathways of the rat, first described by the students of Nils-Åke Hillarp in Sweden, provided the basis for a neurocircuitry targeted pharmacology, leading to important therapeutic ...