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Gap Junction Intercellular Communications Regulate NK Cell Activation and Modulate NK Cytotoxic Capacity
(2014)
Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune system, mediates Ag transfer between human dendritic cells ...
Comparative Analysis of Activation Phenotype, Proliferation, and IFN-gamma Production by Spleen NK1.1(+) and NK1.1(-) T Cells During Plasmodium chabaudi AS Malaria
(MARY ANN LIEBERT INC, 2010)
The NK1.1 molecule participates in NK, NKT, and T-cell activation, contributing to IFN-gamma production and cytotoxicity. To characterize the early immune response to Plasmodium chabaudi AS, spleen NK1.1(+) and NK1.1(-) T ...
Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: the case of IL-27
(Frontiers, 2017-01)
Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ. Activation of these effector functions ...
Natural killer cell activity in experimental paracoccidioidomycosis of the Syrian hamster
(Instituto de Medicina Tropical, 1995-04-01)
Com o objetivo de avaliar a atividade de células natural killer na paracoccidioidomicose experimental do hamster, 80 hamsters foram infectados por via intratesticular com Paracoccidioides brasiliensis e sacrificados após ...
Uterine natural killer cells are immunogenic in syngeneic male mice
(Elsevier Ireland LtdClareIrlanda, 2008)
Heterogeneity in composition of mouse uterine natural killer cell granules
(Federation Amer Soc Exp BiolBethesdaEUA, 2012)
Natural killer cells as helper cells in dendritic cell cancer vaccines
(Frontiers Research Foundation, 2015-01)
Vaccine-based cancer immunotherapy has generated highly variable clinical results due to differing methods of vaccine preparation and variation in patient populations among other lesser factors. Moreover, these clinical ...
IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness
(Wiley, 2015-01-13)
IL-27, a member of the IL-12 family of cytokines, is produced by APCs, and displays pro- and anti-inflammatory effects. How IL-27 affects human NK cells still remain unknown. In this study, we observed that mature dendritic ...
Immunological alterations in patients with primary tumors in central nervous system
(1999-09-01)
Natural killer (NK) cells play an important role in immune surveillance against tumors. The present work aimed to study the cytotoxic activity of NK cells and T cell subsets in peripheral blood of 13 patients with primary ...
Human M2 macrophages limit NK cell effector functions through secretion of TGF-b and engagement of CD85j
(American Association of Immunologists, 2018-02-01)
NK cells play important roles during immunosurveillance against tumors and viruses as they trigger cytotoxicity against susceptible cells and secrete pro-inflammatory cytokines such as IFN-g. In addition, upon activation, ...