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Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling
(2013-07-01)
The cysteine proteinase inhibitor cystatin C inhibited RANKL-stimulated osteoclast formation in mouse bone marrow macrophage cultures, an effect associated with decreased mRNA expression of Acp5, Calcr, Ctsk, Mmp9, Itgb3, ...
Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling
(2013-07-01)
The cysteine proteinase inhibitor cystatin C inhibited RANKL-stimulated osteoclast formation in mouse bone marrow macrophage cultures, an effect associated with decreased mRNA expression of Acp5, Calcr, Ctsk, Mmp9, Itgb3, ...
Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis
(Mary Ann Liebert, 2019-06)
Aims: Cardiac fibroblasts (CFs) are emerging as major contributors to myocardial fibrosis (MF), a final common pathway of many etiologies of heart disease. Here, we studied the functional relevance of transient receptor ...
NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis
(Springer Verlag (Germany), 2017)
Transient Receptor Potential Canonical 3 and nuclear factor of activated T cells C3 signaling pathway critically regulates myocardial fibrosis
(Mary Ann Liebert, 2019)
Abstract:
Aims: Cardiac fibroblasts (CFs) are emerging as major contributors to myocardial fibrosis (MF), a final common pathway of many etiologies of heart disease. Here, we studied the functional relevance of transient ...
NFAT Isoforms Regulate Muscle Fiber Type Transition without Altering CaN during Aerobic Training
(Georg Thieme Verlag KgStuttgartAlemanha, 2013)
Miostatina inhibe la vía de señalización IGF-1/PI3K/PLCγ/NFATc3 a través del receptor Activina tipo IB (ActRIB)
(Universidad Andrés Bello, 2017)
Miostatina, un miembro de la familia TGF-β, es una proteína expresada principalmente en el músculo esquelético que cumple un rol inhibidor en la proliferación y diferenciación de células musculares. Miostatina ejerce su ...
Nuclear factor of activated T cells-dependent downregulation of the transcription factor glioma-associated protein 1 (GLI1) underlies the growth inhibitory properties of arachidonic acid
(American Society for Biochemistry and Molecular Biology, 2016-01)
Numerous reports have demonstrated a tumor inhibitory effect of polyunsaturated fatty acids (PUFAs). However, the molecular mechanisms modulating this phenomenon are in part poorly understood. Here, we provide evidence of ...
Immunoregulatory cytokines in mouse placental extracts inhibit in vitro osteoclast differentiation of murine macrophages
(Elsevier, 2012-12)
Introduction
Previous studies showed that placental extracts (PE) alleviates arthritic symptoms in animal models of arthritis.
Methods
To evaluate whether murine PEs obtained at embryonic days 7.5 (PE7) and 17.5 (PE18) ...