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Using the comet and micronucleus assays for genotoxicity studies: a review
(2015)
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these ...
Evaluation of genotoxicity using the micronucleus assay and nuclear abnormalities in the tropical sea fish Bathygobius soporator (Valenciennes, 1837) (Teleostei, Gobiidae)
(2009)
The micronucleus and nuclear abnormalities assays have been used increasingly to evaluate genotoxicity of many compounds in polluted aquatic ecossystems. The aim of this study is to verify the efficiency of the micronucleus ...
Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide
(Sociedade Brasileira de Genética, 2014)
β-glucan is a well-known polysaccharide for its chemopreventive effect. This study aimed to evaluate the chemopreventive ability of β-glucan in somatic and germ cells through the dominant lethal and micronucleus assays, ...
First in vivo evaluation of the mutagenic effect of Brazilian green propolis by comet assay and micronucleus test
(Pergamon-Elsevier B.V. Ltd, 2008-07-01)
Propolis is a hive product containing chiefly beeswax and plant-derived substances such as resin and volatile compounds. Propolis has been used in various parts of the world as an antiseptic and wound healer since ancient ...
First in vivo evaluation of the mutagenic effect of Brazilian green propolis by comet assay and micronucleus test
(Pergamon-Elsevier B.V. Ltd, 2008-07-01)
Propolis is a hive product containing chiefly beeswax and plant-derived substances such as resin and volatile compounds. Propolis has been used in various parts of the world as an antiseptic and wound healer since ancient ...
Evaluation of chemopreventive activity of glutamine by the comet and the micronucleus assay in mice's peripheral blood
(Elsevier B.V., 2009-07-01)
This research has evaluated the effects of enteral supplementation of glutamine in clastogens and genotoxic damages caused by the acute administration of cisplatin. For this. it was utilized Swiss mice distributed in eight ...
High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats
(2016-02-01)
Background: Alcohol exerts teratogenic effects and its consumption during pregnancy can cause deficit of bone development. The aim of the current study was to evaluate the genotoxic effects of prenatal exposure to ethanol ...
Cytoprotective Effect of the Eryngium foetidum “Sacha Culantro” Methanolic Leaf Extract versus Sodium Fluoride Exposed Mice using the Micronucleus Test and the Comet Assay
(Pharmacognosy Network Worldwide, 2019)
Introduction: Eryngium foetidum, commonly known as sacha culantro, is a plant that grows in the Peruvian Amazonian jungle, studied for its high concentration of antioxidant substances and various ethnopharmacological ...